{"id":"spinosad-topical-suspension-0-9","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This results in a rapid onset of action, with the insect typically dying within minutes of exposure to the spinosad. The exact mechanism of action is not fully understood, but it is thought to involve the disruption of normal neurotransmitter function in the insect nervous system.","oneSentence":"Spinosad topical suspension works by activating nicotinic acetylcholine receptors in the insect nervous system, ultimately leading to the death of the insect.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:54.240Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Control of fire ants, harvester ants, and other listed pests in lawns and turf"}]},"trialDetails":[{"nctId":"NCT05310734","phase":"PHASE4","title":"PK and Safety Study of Natroba Topical Suspension 0.9% in Subjects 1 Month to 3 Years 11 Months of Age With Scabies","status":"RECRUITING","sponsor":"Cipher Pharmaceuticals Inc.","startDate":"2022-03-04","conditions":"Scabies","enrollment":50},{"nctId":"NCT02485704","phase":"PHASE3","title":"Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2017-05-10","conditions":"Scabies","enrollment":280},{"nctId":"NCT02485717","phase":"PHASE3","title":"Phase 3 Trial to Assess the Safety and Efficacy of Natroba for the Treatment of Scabies","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2017-05-02","conditions":"Scabies","enrollment":291},{"nctId":"NCT01660321","phase":"PHASE4","title":"Pharmacokinetic (PK) and Tolerance Study of Natroba Topical Suspension in Pediatrics With an Active Head Lice Infestation","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2011-09","conditions":"Pediculosis","enrollment":26},{"nctId":"NCT00545168","phase":"PHASE3","title":"Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2007-09","conditions":"Pediculus Capitis Infestation","enrollment":480},{"nctId":"NCT00545753","phase":"PHASE3","title":"Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice","status":"COMPLETED","sponsor":"ParaPRO LLC","startDate":"2007-09","conditions":"Pediculosis","enrollment":558}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Natroba (spinosad) Topical Suspension, 0.9%"],"phase":"phase_3","status":"active","brandName":"spinosad topical suspension, 0.9%","genericName":"spinosad topical suspension, 0.9%","companyName":"ParaPRO LLC","companyId":"parapro-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Spinosad topical suspension works by activating nicotinic acetylcholine receptors in the insect nervous system, ultimately leading to the death of the insect. Used for Control of fire ants, harvester ants, and other listed pests in lawns and turf.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}