{"id":"sphenopalatine-ganglion-block","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient nasal discomfort or congestion"},{"rate":null,"effect":"Epistaxis (nosebleed)"},{"rate":null,"effect":"Temporary numbness or tingling in nasal/palatal region"},{"rate":null,"effect":"Headache recurrence after procedure"}]},"_chembl":{"chemblId":"CHEMBL2075042","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The sphenopalatine ganglion is a key relay station for parasympathetic innervation to the head and face. By delivering local anesthetic directly to this ganglion via transnasal or other approaches, the procedure blocks pain transmission associated with headaches and facial pain conditions. This interruption of autonomic signaling provides rapid pain relief, particularly for acute migraine and cluster headache attacks.","oneSentence":"A sphenopalatine ganglion block is a minimally invasive procedure that interrupts pain signals by anesthetizing the sphenopalatine ganglion, a parasympathetic nerve cluster in the pterygopalatine fossa.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:48.308Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine headache"},{"name":"Cluster headache"},{"name":"Trigeminal neuralgia"},{"name":"Chronic headache and facial pain"}]},"trialDetails":[{"nctId":"NCT07494383","phase":"NA","title":"Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial","status":"COMPLETED","sponsor":"ISSSTE Hospital Regional \"Gral. Ignacio Zaragoza\"","startDate":"2024-05-21","conditions":"Post-Dural Puncture Headache, Headache","enrollment":26},{"nctId":"NCT06353529","phase":"PHASE4","title":"Postop Pain Management in Pituitary Tumour Patients","status":"RECRUITING","sponsor":"Hamilton Health Sciences Corporation","startDate":"2024-11-25","conditions":"Pituitary, Pain, Postoperative","enrollment":108},{"nctId":"NCT07354464","phase":"PHASE3","title":"Efficacy of Sphenopalatine Block Compared to Blood Patch in the Management of Post-dural Puncture Headaches","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2026-02-19","conditions":"PDPH, Post Dural Puncture Headache","enrollment":80},{"nctId":"NCT07380139","phase":"PHASE1","title":"Dexamethasone vs Dexmedetomidine in Sphenopalatine Ganglion Block for Rhinoplasty Pain","status":"ENROLLING_BY_INVITATION","sponsor":"Ain Shams University","startDate":"2026-02-01","conditions":"Post Operative Pain","enrollment":90},{"nctId":"NCT03970655","phase":"PHASE1, PHASE2","title":"Functional Endoscopic Sinus Surgery Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2019-09-25","conditions":"Chronic Rhinosinusitis (Diagnosis)","enrollment":80},{"nctId":"NCT07370129","phase":"NA","title":"Transnasal Sphenopalatine Ganglion Block for Postoperative Pain and Recovery in Tonsillectomy (TONwoPA)","status":"ENROLLING_BY_INVITATION","sponsor":"Ankara University","startDate":"2025-06-01","conditions":"Post Tonsillectomy Pain, Post Operative Analgesia, Opioid Consumption","enrollment":28},{"nctId":"NCT07345039","phase":"NA","title":"Infraorbital-Infratrochlear Block vs Sphenopalatine Ganglion Block for Postoperative Analgesia in Septorhinoplasty.","status":"RECRUITING","sponsor":"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","startDate":"2026-01-16","conditions":"Postoperative 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Hemorrhage","status":"RECRUITING","sponsor":"Wright State University","startDate":"2024-05-20","conditions":"Aneurysmal Subarachnoid Hemorrhage (aSAH), Headache","enrollment":20},{"nctId":"NCT04069897","phase":"PHASE3","title":"Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Olavs Hospital","startDate":"2019-10-01","conditions":"Migraine Disorders","enrollment":170},{"nctId":"NCT07060586","phase":"NA","title":"The Effect of Sphenopalatine Ganglion Block on Headache and Vasalgia","status":"COMPLETED","sponsor":"University Hospital Bispebjerg and Frederiksberg","startDate":"2025-06-18","conditions":"Vasalgia, Headache, Hangover","enrollment":42},{"nctId":"NCT06929429","phase":"NA","title":"Effect of Bilateral SPG and Infraorbital Nerve Blocks on Recovery After Septorhinoplasty","status":"RECRUITING","sponsor":"Konya City Hospital","startDate":"2025-06-19","conditions":"Quality of 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SURGERY","enrollment":60},{"nctId":"NCT06310200","phase":"PHASE1","title":"Sphenopalatine Ganglion Block and Cold Induced Headaches","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wright State University","startDate":"2025-01-01","conditions":"Cold Induced Headache, Brain Freeze, Cold Induced Cephalgia","enrollment":30},{"nctId":"NCT06787677","phase":"NA","title":"SPG Pulsed Radiofrequency for Chronic Cluster Headache","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-01-24","conditions":"Headache, Cluster","enrollment":108},{"nctId":"NCT06752525","phase":"PHASE4","title":"Opioid Sparing Effect of Sphenopalatine Ganglion Block in Functional Endoscopic Sinus Surgery: a Randomized Controlled Clinical Trial.","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-01-01","conditions":"Sinus Surgery","enrollment":60},{"nctId":"NCT06705244","phase":"NA","title":"Trans-nasal Sphenopalatine Ganglion Block Versus Ultrasound-guided Bilateral Greater and Lesser Occipital Nerve Block for Management of Post-Dural Puncture Headache.","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-03-06","conditions":"Post-Dural Puncture Headache","enrollment":50},{"nctId":"NCT03944876","phase":"PHASE3","title":"Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache","status":"RECRUITING","sponsor":"Norwegian University of Science and Technology","startDate":"2019-11-01","conditions":"Cluster Headache","enrollment":112},{"nctId":"NCT06695624","phase":"NA","title":"Effectiveness of Bilateral Endoscopic Sphenopalatine Ganglion Block on Postoperative Pain After Septoplasty","status":"NOT_YET_RECRUITING","sponsor":"Umraniye Education and Research Hospital","startDate":"2024-11","conditions":"Postoperative Pain","enrollment":50},{"nctId":"NCT05365880","phase":"PHASE2","title":"Sphenopalatine Ganglion Block for the Treatment of Post-Stroke 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Chronic Migraine","status":"COMPLETED","sponsor":"Tian Medical Inc.","startDate":"2017-09-20","conditions":"Headache, Migraine","enrollment":174},{"nctId":"NCT06157970","phase":"","title":"Sphenopalatine Ganglion Block in Septorhinoplasty","status":"COMPLETED","sponsor":"Istanbul Medeniyet University","startDate":"2023-06-07","conditions":"Pain, Postoperative, Rhinoplasty","enrollment":50},{"nctId":"NCT05513209","phase":"NA","title":"Opioid Free Pterygopalatine Ganglion Block Based Multimodal Anesthesia for Tonsillectomy Operations","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-09-01","conditions":"PREVENTION OF POSTTONSILLECTOMY PAIN, DECREASE POSTTONSILLECTOMY NAUSEA AND VOMITTING, DECREASE POSTOPERATIVE HOSPITAL STAY","enrollment":90},{"nctId":"NCT03112720","phase":"PHASE3","title":"Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache","status":"TERMINATED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2016-09","conditions":"Postdural Puncture Headache","enrollment":8},{"nctId":"NCT05552404","phase":"PHASE4","title":"Postdural Puncture Headache Relief With Aminophylline and SPGB","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-10-01","conditions":"Anesthesia","enrollment":75},{"nctId":"NCT04515901","phase":"NA","title":"Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches","status":"WITHDRAWN","sponsor":"McMaster University","startDate":"2021-12-01","conditions":"Postdural Puncture Headache","enrollment":""},{"nctId":"NCT03560349","phase":"PHASE2","title":"RCT of SPG Blocks for Post-dural Headache","status":"WITHDRAWN","sponsor":"University of Utah","startDate":"2018-07-01","conditions":"Post-Dural Puncture Headache","enrollment":""},{"nctId":"NCT05235256","phase":"NA","title":"Sphenopalatine Block Versus Greater Occipital Nerve Block in PDPH","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-01-10","conditions":"Post-Dural Puncture Headache","enrollment":120},{"nctId":"NCT04844229","phase":"NA","title":"Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment of Obstetric Post-Dural Puncture Headache","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2021-06-20","conditions":"Post-Dural Puncture Headache","enrollment":42},{"nctId":"NCT05557500","phase":"NA","title":"Assessment of Psychological Symptoms Among Fibromyalgia Patients","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-09-25","conditions":"Psychological Symptoms in Fibromyalgia Patients","enrollment":40},{"nctId":"NCT04650282","phase":"PHASE2","title":"Sphenopalatine Ganglion Block for Headache After Concussion","status":"TERMINATED","sponsor":"University of Michigan","startDate":"2021-03-18","conditions":"Concussion, Headache","enrollment":2},{"nctId":"NCT05269147","phase":"NA","title":"Lidocaine Versus Bupivacaine for Sphenopalatine Ganglion Block","status":"COMPLETED","sponsor":"Huda Fahmy Mahmoud, PhD","startDate":"2022-03-01","conditions":"Septum; Deviation, Congenital","enrollment":60},{"nctId":"NCT05361642","phase":"NA","title":"Regional Nasal Block and Dexmedetomidine in Endoscopic Sinus Surgery","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-02-03","conditions":"Drug Use","enrollment":70},{"nctId":"NCT03430531","phase":"PHASE2","title":"Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache","status":"TERMINATED","sponsor":"Milton S. Hershey Medical Center","startDate":"2019-05-31","conditions":"Post-Dural Puncture Headache, Sphenopalatine Ganglion Block","enrollment":6},{"nctId":"NCT04636034","phase":"PHASE3","title":"The Effect of Ganglion Sphenopalatine Block Versus Placebo on Persistent Headache Following COVID-19 Infection","status":"TERMINATED","sponsor":"University Hospital Bispebjerg and Frederiksberg","startDate":"2021-01-12","conditions":"Headache, Covid19, Sphenopalatine Ganglion Block","enrollment":18},{"nctId":"NCT05301387","phase":"","title":"The Effect of Ganglion Sphenopalatine Block (GSP-block) Follow-Up","status":"COMPLETED","sponsor":"University Hospital Bispebjerg and Frederiksberg","startDate":"2021-11-26","conditions":"Post-Dural Puncture Headache, Ganglion Sphenopalatine Block","enrollment":38},{"nctId":"NCT05253014","phase":"NA","title":"Different Approaches for the Management of Post-dural Puncture Headache","status":"COMPLETED","sponsor":"Bahaa Mohammed Refaie","startDate":"2018-01-01","conditions":"Post-Dural Puncture Headache","enrollment":120},{"nctId":"NCT04793490","phase":"NA","title":"Sphenopalatine Ganglion Block for Management of Post- Dural Puncture Headache in Obstetric Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-03-15","conditions":"Post-Dural Puncture Headache","enrollment":40},{"nctId":"NCT05213065","phase":"NA","title":"Assessment of the Efficacy of the Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Daily Headache in Children and Adolescents.","status":"UNKNOWN","sponsor":"Pablo Ingelmo","startDate":"2022-02-05","conditions":"Chronic Daily Headache, Post-Traumatic Headache","enrollment":120},{"nctId":"NCT05210192","phase":"PHASE3","title":"Sphenopalatine Ganglion Blockade in Migraine","status":"UNKNOWN","sponsor":"Afyonkarahisar Health Sciences University","startDate":"2022-04-01","conditions":"Episodic Migraine","enrollment":50},{"nctId":"NCT03462290","phase":"PHASE2","title":"Botox Injections for Patients With Persistent Facial Pain","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2018-05-01","conditions":"Facial Pain","enrollment":31},{"nctId":"NCT05136625","phase":"NA","title":"Sphenopalatine Ganglion Block and Pain Management in Neurosurgery","status":"UNKNOWN","sponsor":"University Hospital of Ferrara","startDate":"2021-02-01","conditions":"Post Operative Pain, Craniofacial Pain","enrollment":84},{"nctId":"NCT03984045","phase":"PHASE3","title":"SPG Block for Acute Pediatric Migraine","status":"UNKNOWN","sponsor":"Newark Beth Israel Medical Center","startDate":"2019-06-06","conditions":"Migraine in Children, Sphenopalatine Neuralgia, Migraine in Adolescence","enrollment":72},{"nctId":"NCT02784262","phase":"PHASE2","title":"Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2016-10","conditions":"Chronic Disease, Nasal Polyposis, Rhinitis","enrollment":11},{"nctId":"NCT03567590","phase":"NA","title":"The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2018-07-05","conditions":"Cluster Headache","enrollment":80},{"nctId":"NCT04479176","phase":"","title":"Comparison of Two Methods of Transnasal Sphenopalatine Ganglion Block","status":"COMPLETED","sponsor":"Ajou University School of Medicine","startDate":"2021-03-10","conditions":"Sphenopalatine Ganglion Block","enrollment":74},{"nctId":"NCT03666663","phase":"PHASE4","title":"Sphenopalatine Ganglion Blocks RCT","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2019-02-01","conditions":"Migraine","enrollment":10},{"nctId":"NCT04434651","phase":"NA","title":"Effect of SPGB on ICP and Oxygenation of Cerebral Venous Outflow in Craniotomy for Cerebral Tumors.","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2020-06-17","conditions":"Cerebral Tumor","enrollment":52},{"nctId":"NCT04401878","phase":"NA","title":"SGB in Management of Patients With PDPH Using TCD","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2020-05-24","conditions":"Post-Dural Puncture Headache","enrollment":120},{"nctId":"NCT04892290","phase":"","title":"Sphenopalatine Ganglion Block for Postdural Puncture Headache","status":"COMPLETED","sponsor":"Sakarya University","startDate":"2019-12-01","conditions":"Postdural Puncture Headache","enrollment":110},{"nctId":"NCT04466826","phase":"PHASE2","title":"Transnasal Sphenopalatine Ganglia Block for Management of Chronic Migraines in Pediatric Patients","status":"WITHDRAWN","sponsor":"Washington University School of Medicine","startDate":"2021-01-02","conditions":"Migraine in Children, Pain, Neuropathic","enrollment":""},{"nctId":"NCT04657952","phase":"PHASE4","title":"Sphenopalatine Ganglion Block for Post-Dural Puncture Headache in Orthopedic Patients","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2020-12-10","conditions":"Sphenopalatine Ganglion Block, Adrenaline, Post-Dural Puncture Headache","enrollment":60},{"nctId":"NCT03966547","phase":"NA","title":"Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714","status":"WITHDRAWN","sponsor":"University Hospital Bispebjerg and Frederiksberg","startDate":"2020-05","conditions":"Postdural Puncture Headache, Sphenopalatine Ganglion Block","enrollment":""},{"nctId":"NCT04255420","phase":"PHASE4","title":"SPG Blocks for Headaches","status":"UNKNOWN","sponsor":"Kendall Healthcare Group, Ltd.","startDate":"2020-02-21","conditions":"Headache","enrollment":84},{"nctId":"NCT03156049","phase":"NA","title":"Sphenopalatine Ganglion Block Versus Occiptal Nerve Block in Treatment of Post Dural Puncture Headache","status":"COMPLETED","sponsor":"Assiut University","startDate":"2017-07-14","conditions":"Headache","enrollment":93},{"nctId":"NCT04353505","phase":"PHASE1","title":"Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache","status":"WITHDRAWN","sponsor":"Weill Medical College of Cornell University","startDate":"2020-10","conditions":"Chronic Migraine, Cluster Headache, Trigeminal Neuralgia","enrollment":""},{"nctId":"NCT04339231","phase":"NA","title":"Block of the Sphenopalatine Nerve Ganglion for Postoperative Analgesia","status":"UNKNOWN","sponsor":"Universidade Federal Fluminense","startDate":"2020-04-25","conditions":"Surgery, Anesthesia, Local, Postoperative Pain","enrollment":40},{"nctId":"NCT02984618","phase":"NA","title":"Sphenopalatine Block or Epidural Bloodpatch for Post Dural Puncture Headache: Randomized Controlled Trial","status":"TERMINATED","sponsor":"Brasilia University Hospital","startDate":"2016-12-01","conditions":"Post-Dural Puncture Headache","enrollment":19},{"nctId":"NCT02962427","phase":"PHASE4","title":"Treatment of Post-dural Puncture Headache in Postpartum Patients: Sphenopalatine Ganglion Block to Epidural Blood Patch.","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2016-11","conditions":"Headache","enrollment":4},{"nctId":"NCT04148846","phase":"NA","title":"Sphenopalatine Blockade Versus Clinical Treatment","status":"UNKNOWN","sponsor":"University of Sao Paulo General Hospital","startDate":"2019-09-20","conditions":"Headache, Post-Dural Puncture","enrollment":45},{"nctId":"NCT03171090","phase":"NA","title":"Efficacy of Bilateral Ultrasonic Guided Sphenopalatine Ganglion Block in Maxilofacial Cancer Surgeries","status":"COMPLETED","sponsor":"Assiut University","startDate":"2017-06-05","conditions":"Maxillofacial Tumors","enrollment":48},{"nctId":"NCT02517931","phase":"NA","title":"Sphenopalatine Ganglion Block for Postdural Puncture Headache in the Emergency Department","status":"WITHDRAWN","sponsor":"University of Arkansas","startDate":"2019-01-01","conditions":"Postdural Puncture Headache","enrollment":""},{"nctId":"NCT04101019","phase":"NA","title":"Sphenopalatine Ganglion Block to Treat Shoulder Pain After Laparoscopic Surgery","status":"UNKNOWN","sponsor":"Rabin Medical Center","startDate":"2019-09","conditions":"Nerve Block","enrollment":76},{"nctId":"NCT03652714","phase":"PHASE3","title":"The Effect of Ganglion Sphenopalatine Block (GSP-block) Versus Placebo on Postdural Puncture Headache","status":"COMPLETED","sponsor":"University Hospital Bispebjerg and Frederiksberg","startDate":"2018-09-19","conditions":"Postdural Puncture Headache, Sphenopalatine 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