{"id":"spc-ezetimibe-rosuvastatin","safety":{"commonSideEffects":[{"rate":"null","effect":"Muscle pain"},{"rate":"null","effect":"Liver enzyme elevations"},{"rate":"null","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ezetimibe works by binding to the Niemann-Pick C1-like 1 (NPC1L1) protein in the small intestine, preventing the absorption of cholesterol from the diet. Rosuvastatin, on the other hand, is a statin that inhibits the enzyme HMG-CoA reductase, which is responsible for the production of cholesterol in the liver. By inhibiting this enzyme, rosuvastatin reduces the liver's production of cholesterol, leading to a decrease in circulating cholesterol levels.","oneSentence":"Ezetimibe inhibits the absorption of cholesterol in the small intestine, while rosuvastatin inhibits HMG-CoA reductase to reduce cholesterol production in the liver.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:44.648Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia"},{"name":"Mixed dyslipidemia"}]},"trialDetails":[{"nctId":"NCT04669041","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and the Safety of Single Pill Combination (SPC) Ezetimibe/Rosuvastatin in Chinese Adult Patients With Primary Hypercholesterolemia Not Adequately Controlled on Statin Therapy","status":"COMPLETED","sponsor":"Sanofi","startDate":"2020-12-08","conditions":"Hypercholesterolemia","enrollment":305}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SPC ezetimibe/rosuvastatin","genericName":"SPC ezetimibe/rosuvastatin","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SPC ezetimibe/rosuvastatin is a single pill combination used to treat hypercholesterolemia. It works as a small molecule inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, which is involved in cholesterol production.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}