{"id":"sp-plus-amodiaquine","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The combination of SP (sulfadoxine and pyrimethamine) and amodiaquine is synergistic in its action against the malaria parasite. SP inhibits dihydropteroate synthase, an enzyme essential for the parasite's folate synthesis, while amodiaquine targets the parasite's DNA and interferes with its replication.","oneSentence":"SP plus amodiaquine is a combination antimalarial medication that works by targeting the malaria parasite's life cycle.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:37.667Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Prevention of malaria in areas with high transmission"}]},"trialDetails":[{"nctId":"NCT07322068","phase":"PHASE4","title":"Perennial Malaria Chemoprevention in the Malaria Vaccine Era","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-09","conditions":"Malaria, Falciparum","enrollment":1290},{"nctId":"NCT06083688","phase":"PHASE4","title":"Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi","status":"ACTIVE_NOT_RECRUITING","sponsor":"Liverpool School of Tropical Medicine","startDate":"2024-10-14","conditions":"Malaria,Falciparum, Anemia in Children","enrollment":1000},{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT00131703","phase":"PHASE3","title":"Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-03","conditions":"Malaria, Pregnancy","enrollment":900},{"nctId":"NCT06225297","phase":"PHASE4","title":"Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, 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Chemoprevention","enrollment":1000},{"nctId":"NCT05471544","phase":"PHASE3","title":"Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-18","conditions":"Malaria","enrollment":3575},{"nctId":"NCT06182176","phase":"NA","title":"Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-05-27","conditions":"Malaria, Soil Transmitted Helminths, Schistosomiasis","enrollment":1200},{"nctId":"NCT05946642","phase":"PHASE3","title":"Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2023-07-15","conditions":"Malaria","enrollment":13000},{"nctId":"NCT05478954","phase":"PHASE4","title":"Chemoprevention 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Malaria","enrollment":650},{"nctId":"NCT02831023","phase":"PHASE2","title":"Phase 2 Efficacy Study of Primaquine and Methylene Blue","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-07","conditions":"Malaria","enrollment":80},{"nctId":"NCT00432367","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-02","conditions":"Malaria, Anaemia, Pregnancy","enrollment":3333},{"nctId":"NCT01319448","phase":"PHASE1, PHASE2","title":"Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2011-09","conditions":"Malaria, Sickle Cell Crisis","enrollment":270},{"nctId":"NCT01634945","phase":"NA","title":"Efficacy of Iron Fortified Complementary Food and IPT of Malaria in Young Children in Côte d'Ivoire","status":"COMPLETED","sponsor":"Swiss Federal Institute of Technology","startDate":"2012-04","conditions":"Anemia","enrollment":629},{"nctId":"NCT00164710","phase":"PHASE4","title":"Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2005-04","conditions":"Malaria, Falciparum","enrollment":365},{"nctId":"NCT00941785","phase":"PHASE2, PHASE3","title":"Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2009-07","conditions":"Malaria","enrollment":1500},{"nctId":"NCT00738946","phase":"NA","title":"A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-08","conditions":"Malaria","enrollment":6000},{"nctId":"NCT00712374","phase":"PHASE4","title":"Evaluation of the Public Health Impact of Seasonal Intermittent Preventive Treatment (IPT) in Children in Senegal","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2008-09","conditions":"Malaria","enrollment":100000},{"nctId":"NCT00118807","phase":"PHASE3","title":"Trial of the Effectiveness of AQ/AS, SP/AQ and SP/CQ for Uncomplicated Malaria in Gambian Children","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2003-08","conditions":"Malaria","enrollment":1800}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Camoquin","Fansidar"],"phase":"phase_3","status":"active","brandName":"SP plus amodiaquine","genericName":"SP plus amodiaquine","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SP plus amodiaquine is a combination antimalarial medication that works by targeting the malaria parasite's life cycle. Used for Treatment of uncomplicated malaria caused by Plasmodium falciparum, Prevention of malaria in areas with high transmission.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}