{"id":"sp-ms-day-before-only-dosing","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Electrolyte imbalance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium picosulfate is a stimulant laxative that increases intestinal motility and fluid secretion, while magnesium sulfate acts as an osmotic laxative to draw water into the bowel lumen. Together, they produce rapid bowel evacuation to clear fecal matter and prepare the colon for endoscopic visualization. The day-before-only dosing schedule aims to simplify the preparation regimen compared to split-dose protocols.","oneSentence":"SP+MS is a bowel preparation regimen combining sodium picosulfate and magnesium sulfate administered the day before a procedure to cleanse the colon.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:35:38.445Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy"},{"name":"Bowel cleansing prior to other colorectal procedures"}]},"trialDetails":[{"nctId":"NCT02273141","phase":"PHASE3","title":"Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults.","status":"COMPLETED","sponsor":"Norgine","startDate":"2014-11","conditions":"Colorectal Cancer, Colorectal Carcinoma, Colon Cleansing","enrollment":515}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SP+MS, Day Before-Only Dosing","genericName":"SP+MS, Day Before-Only Dosing","companyName":"Norgine","companyId":"norgine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SP+MS, also known as a sodium picosulfate and magnesium salt solution, is a small molecule used for bowel cleansing. It is studied in a day before-only dosing regimen for conditions such as colorectal cancer, colorectal carcinoma, and colon cleansing.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}