{"id":"sp-iptp","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1672558","moleculeType":"Small molecule","molecularWeight":"450.51"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination therapy works by inhibiting folate metabolism (via sulfadoxine-pyrimethamine) and disrupting the malaria parasite's hemozoin formation (via piperaquine), providing prolonged antimalarial protection. SP-IPTp is administered as intermittent preventive treatment during pregnancy to reduce maternal malaria, anemia, and adverse birth outcomes, and in children as seasonal malaria chemoprevention during high-transmission periods.","oneSentence":"SP-IPTp is a seasonal malaria chemoprevention regimen combining sulfadoxine-pyrimethamine with piperaquine to prevent malaria in pregnant women and children.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:47.634Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intermittent preventive treatment of malaria in pregnancy (IPTp)"},{"name":"Seasonal malaria chemoprevention in children aged 3–59 months"}]},"trialDetails":[{"nctId":"NCT04336189","phase":"PHASE3","title":"Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda","status":"COMPLETED","sponsor":"Grant Dorsey, M.D, Ph.D.","startDate":"2020-12-28","conditions":"Malaria","enrollment":2757},{"nctId":"NCT05471544","phase":"PHASE3","title":"Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-18","conditions":"Malaria","enrollment":3575},{"nctId":"NCT05478954","phase":"PHASE4","title":"Chemoprevention Efficacy Study in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-15","conditions":"Malaria","enrollment":800},{"nctId":"NCT03998839","phase":"","title":"TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study","status":"COMPLETED","sponsor":"Jhpiego","startDate":"2018-03-05","conditions":"Malaria in Pregnancy","enrollment":7200},{"nctId":"NCT04189744","phase":"PHASE3","title":"The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2019-12-15","conditions":"Pregnancy Malaria, Bacterial Vaginoses, Trichomonas Vaginitis","enrollment":5436},{"nctId":"NCT04147546","phase":"PHASE3","title":"Additional Screening With Sensitives RDTs and Malaria","status":"COMPLETED","sponsor":"Institut de Recherche en Sciences de la Sante, Burkina Faso","startDate":"2020-08-31","conditions":"Plasmodium Falciparum Malaria, Malaria Diagnosis","enrollment":340},{"nctId":"NCT04783051","phase":"PHASE3","title":"Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)","status":"COMPLETED","sponsor":"University of Kinshasa","startDate":"2021-05-06","conditions":"Malaria in Pregnancy","enrollment":250},{"nctId":"NCT03208179","phase":"PHASE3","title":"Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2018-03-29","conditions":"Pregnancy, Malaria in Pregnancy, Malaria","enrollment":4680},{"nctId":"NCT03600844","phase":"NA","title":"Evaluating the Effects of Community Delivery of Malaria Intermittent Preventive Treatment on Pregnant Women and Babies","status":"COMPLETED","sponsor":"Jhpiego","startDate":"2018-04-02","conditions":"Malaria in Pregnancy","enrollment":10602},{"nctId":"NCT03376217","phase":"NA","title":"Assessing the Effectiveness of Community Delivery of Intermittent Preventive Treatment in Pregnancy (IPTp) in Malawi","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2017-12-01","conditions":"Malaria in Pregnancy","enrollment":1447},{"nctId":"NCT03009526","phase":"PHASE3","title":"Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi","status":"COMPLETED","sponsor":"Kamuzu University of Health Sciences","startDate":"2017-01-17","conditions":"Malaria, Pregnancy","enrollment":602},{"nctId":"NCT04160026","phase":"PHASE4","title":"Acceptability and Feasibility in the Context of the IMPROVE Trial in Kenya","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2019-11-11","conditions":"Malaria in Pregnancy, Adherence, Treatment","enrollment":1600},{"nctId":"NCT04634695","phase":"","title":"Assessing to What Extent Dhps-431V Mutation May Influence the Protective Efficacy of IPTp-SP","status":"UNKNOWN","sponsor":"Obafemi Awolowo University","startDate":"2020-08-10","conditions":"Pregnancy Malaria","enrollment":288},{"nctId":"NCT01669941","phase":"PHASE4","title":"Efficacy of Intermittent Screening and Treatment or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya","status":"COMPLETED","sponsor":"Kenya Medical Research Institute","startDate":"2012-08","conditions":"Pregnancy, Malaria","enrollment":1546},{"nctId":"NCT01443130","phase":"PHASE3","title":"Chloroquine for Malaria in Pregnancy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2012-02","conditions":"Malaria","enrollment":900},{"nctId":"NCT00432367","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-02","conditions":"Malaria, Anaemia, Pregnancy","enrollment":3333},{"nctId":"NCT01103063","phase":"PHASE3","title":"Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa","status":"TERMINATED","sponsor":"Pfizer","startDate":"2010-10","conditions":"Intermittent Preventive Treatment In Pregnancy (IPTp)","enrollment":2891},{"nctId":"NCT01084213","phase":"PHASE4","title":"Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2010-06","conditions":"Malaria, Pregnancy, Anaemia","enrollment":5354},{"nctId":"NCT00811421","phase":"NA","title":"Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2009-09","conditions":"Pregnancy, Malaria, HIV Infections","enrollment":5820},{"nctId":"NCT01636895","phase":"PHASE4","title":"Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria","status":"UNKNOWN","sponsor":"Malaria Consortium, UK","startDate":"2011-01","conditions":"Pregnancy Complications Parasitic","enrollment":600},{"nctId":"NCT00730366","phase":"PHASE3","title":"New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2004-03","conditions":"Malaria in Pregnancy","enrollment":2766},{"nctId":"NCT00964691","phase":"PHASE4","title":"A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands","status":"TERMINATED","sponsor":"Ministry of Health and Medical Services, Solomon Islands","startDate":"2009-08","conditions":"Malaria, Malaria in Pregnancy","enrollment":2504}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":47,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SP"],"phase":"marketed","status":"active","brandName":"SP-IPTp","genericName":"SP-IPTp","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SP-IPTp is a seasonal malaria chemoprevention regimen combining sulfadoxine-pyrimethamine with piperaquine to prevent malaria in pregnant women and children. Used for Intermittent preventive treatment of malaria in pregnancy (IPTp), Seasonal malaria chemoprevention in children aged 3–59 months.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}