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This leads to the death of the parasites and ultimately, the clearance of the infection.","oneSentence":"Sulfadoxine and pyrimethamine work by inhibiting dihydropteroate synthase and dihydrofolate reductase, respectively, disrupting folic acid synthesis in Plasmodium parasites.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:37.542Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria, Cerebral malaria"}]},"trialDetails":[{"nctId":"NCT07322068","phase":"PHASE4","title":"Perennial Malaria Chemoprevention in the Malaria Vaccine Era","status":"NOT_YET_RECRUITING","sponsor":"Stanford University","startDate":"2026-09","conditions":"Malaria, Falciparum","enrollment":1290},{"nctId":"NCT06083688","phase":"PHASE4","title":"Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi","status":"ACTIVE_NOT_RECRUITING","sponsor":"Liverpool School of Tropical 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