{"id":"soolantra-ivermectin-cream-1","brandName":"Soolantra® Ivermectin cream 1%","genericName":"Soolantra® Ivermectin cream 1%","companyId":"zydus-worldwide-dmcc","companyName":"Zydus Worldwide DMCC","phase":"phase_3","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Soolantra® (Ivermectin 1% cream) is a topical antiparasitic developed by Zydus Worldwide DMCC for the treatment of moderate to severe facial rosacea. It has completed Phase 3 trials and is not yet FDA-approved. The drug has shown good safety and efficacy in clinical trials, with common side effects including application site reactions.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivermectin works primarily by disrupting neurotransmission in parasites, causing paralysis and death. In rosacea, it is thought to reduce inflammation by suppressing innate immune activation, decreasing pro-inflammatory cytokine production, and potentially reducing the population of Demodex mites that may contribute to disease pathogenesis.","oneSentence":"Ivermectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites and may modulate innate immune responses in the skin.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or burning"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Dryness"}]},"trials":[],"indications":{"approved":[{"name":"Rosacea (inflammatory lesions)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}