{"id":"sonovue","safety":{"commonSideEffects":[{"rate":"null","effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by producing a large number of microbubbles that reflect sound waves, allowing for improved visualization of blood flow and tissue perfusion.","oneSentence":"SonoVue is a microbubble ultrasound contrast agent that enhances ultrasound imaging.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:27.245Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Enhanced ultrasound imaging of the liver, spleen, and other organs"}]},"trialDetails":[{"nctId":"NCT04196543","phase":"NA","title":"Interest of a Post-operative Ultrasound With Systematic Use of Ultrasonic Contrast in the Follow-up of Aortic Endoprosthesis: Prospective Study at the University Hospital of Nice","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2020-02-28","conditions":"Aneurysm, Abdominal Aortic","enrollment":40},{"nctId":"NCT06400004","phase":"PHASE3","title":"Lumason® Infusion vs. Bolus Administrations","status":"RECRUITING","sponsor":"Bracco Diagnostics, Inc","startDate":"2024-07-10","conditions":"Heart Diseases","enrollment":106},{"nctId":"NCT07385846","phase":"PHASE1","title":"Pilot Study of Navigated Focused Ultrasound and Pembrolizumab in the Treatment of Recurrent WHO Grade 4 IDH-Wildtype Glioblastoma With Mismatch Repair Deficiency","status":"NOT_YET_RECRUITING","sponsor":"Jennifer Leddon","startDate":"2026-06-01","conditions":"Glioblastoma, Mismatch Repair Deficiency","enrollment":8},{"nctId":"NCT07313878","phase":"NA","title":"Evaluation of Acute and Chronic Nephrotoxicity in Acute Lymphatic Leukemia Patients Using Ultrasound Localization Microscopy","status":"RECRUITING","sponsor":"University of Erlangen-Nürnberg Medical School","startDate":"2025-11-19","conditions":"Acute Lymphoblastic Leukaemias (ALL), Long Term Follow-Up","enrollment":30},{"nctId":"NCT02302573","phase":"NA","title":"Placenta Accreta : Contrast-enhanced Ultrasound Analysis in High Risk Population","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2009-05","conditions":"Placenta Accreta","enrollment":80},{"nctId":"NCT07298655","phase":"NA","title":"3D Contrast Enhanced Microvascular Ultrasound of Carotid Atherosclerosis for the Detection of Carotid Plaque Neo-Revascularisation.","status":"RECRUITING","sponsor":"London North West Healthcare NHS Trust","startDate":"2025-10-16","conditions":"Carotid Atherosclerosis, Ultrasound, Plaque Neovascularization","enrollment":10},{"nctId":"NCT07113808","phase":"","title":"Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China","status":"RECRUITING","sponsor":"The Children's Hospital of Zhejiang University School of Medicine","startDate":"2024-09-10","conditions":"Abdominal Neoplasm, Abdominal Injury, Ascites","enrollment":108},{"nctId":"NCT02201537","phase":"NA","title":"Kidney Disease and Ultrasound Imaging","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2013-03-19","conditions":"Recipient of Kidney Transplant","enrollment":141},{"nctId":"NCT07193225","phase":"NA","title":"Microflow3D - Non-invasive Mapping of Coronary Arteries and the Cerebral Vascular Network Using 3D Ultrasound Localization Microscopy in Patients With Atherosclerosis Prior to Carotid Endarterectomy Surgery","status":"NOT_YET_RECRUITING","sponsor":"French Cardiology Society","startDate":"2025-11-01","conditions":"Carotid Atherosclerosis","enrollment":37},{"nctId":"NCT01880554","phase":"NA","title":"Ultrasound Liver Intraoperative Imaging With SonoVue®","status":"COMPLETED","sponsor":"Institut Bergonié","startDate":"2011-06","conditions":"Liver Metastases From Colorectal Primary Cancer","enrollment":68},{"nctId":"NCT06677554","phase":"PHASE3","title":"Contribution of Contrast Enhanced Ultrasound for Diagnosis of Adnexal Torsion","status":"RECRUITING","sponsor":"Central Hospital, Nancy, France","startDate":"2025-05-14","conditions":"Adnexal Torsion","enrollment":256},{"nctId":"NCT04720456","phase":"PHASE2","title":"SHAPE of Portal Hypertension in Children","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2021-11-03","conditions":"Hypertension, Portal","enrollment":120},{"nctId":"NCT06496971","phase":"PHASE3","title":"A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients","status":"RECRUITING","sponsor":"NaviFUS Corporation","startDate":"2024-11-08","conditions":"Glioblastoma Multiforme, Glioblastoma, Glioblastoma Multiforme, Adult","enrollment":32},{"nctId":"NCT04470687","phase":"NA","title":"Ultrafast Ultrasound Imaging Assesment of Carotid Plaque Neovascularization","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-03-17","conditions":"Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis","enrollment":40},{"nctId":"NCT03907657","phase":"PHASE2","title":"Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2019-09-23","conditions":"Von-Hippel Lindau, Kidney Disease, Chronic","enrollment":15},{"nctId":"NCT04522219","phase":"PHASE3","title":"Contribution of Contrast Enhanced Ultrasound in the Diagnosis of Adnexal Torsion","status":"TERMINATED","sponsor":"Central Hospital, Nancy, France","startDate":"2021-04-13","conditions":"Adnexal Torsion","enrollment":11},{"nctId":"NCT05445050","phase":"NA","title":"mULM to Support Breast Cancer Diagnosis and Therapy","status":"UNKNOWN","sponsor":"RWTH Aachen University","startDate":"2021-04-26","conditions":"Primary Breast Cancer","enrollment":74},{"nctId":"NCT04021238","phase":"PHASE2","title":"Contrast-Enhanced Ultrasound for Kidney Cancer Subtyping and Staging","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2020-10-07","conditions":"Kidney Cancer","enrollment":25},{"nctId":"NCT04085094","phase":"","title":"Gender Differences in Renal Functioning and Disease","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Vaudois","startDate":"2017-05-30","conditions":"Chronic Renal Failure, Healthy Controls","enrollment":98},{"nctId":"NCT04446416","phase":"NA","title":"Efficacy and Safety of NaviFUS System add-on Bevacizumab (BEV) in Recurrent GBM Patients","status":"COMPLETED","sponsor":"NaviFUS Corporation","startDate":"2020-07-21","conditions":"Glioblastoma Multiforme, Glioblastoma, Glioma","enrollment":6},{"nctId":"NCT04841616","phase":"NA","title":"Multicentered Prospective Randomized Controlled Trial For Solid Pancreatic Lesions","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2021-07-01","conditions":"Pancreas Neoplasm","enrollment":128},{"nctId":"NCT04305561","phase":"NA","title":"Preoperative Localization Strategies in Primary Hyperparathyroidism","status":"COMPLETED","sponsor":"Odense University Hospital","startDate":"2019-09-05","conditions":"Primary Hyperparathyroidism","enrollment":172},{"nctId":"NCT05051423","phase":"","title":"\"Mechanisms and Biomarkers of Response and Resistance to Current Targeted Therapies in Gastric Cancer\" (THERRES)","status":"UNKNOWN","sponsor":"University of Medicine and Pharmacy Craiova","startDate":"2019-11-01","conditions":"Gastric Cancer","enrollment":40},{"nctId":"NCT02552238","phase":"PHASE3","title":"Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-142","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2015-10-12","conditions":"Coronary Artery Disease","enrollment":174},{"nctId":"NCT02522481","phase":"PHASE3","title":"Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-141","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2015-09-24","conditions":"Coronary Artery Disease","enrollment":175},{"nctId":"NCT03068403","phase":"NA","title":"Dynamic Contrast Enhanced Ultrasound for Predict and Assess Rectal Cancer Response After Neo-adjuvant Chemoradiation - RECT","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2018-06-18","conditions":"Rectal Cancer","enrollment":2},{"nctId":"NCT02884297","phase":"PHASE3","title":"HexafluOride, a Contrast Agent for Placenta Echo-angiography","status":"COMPLETED","sponsor":"Centre Hospitalier Régional Metz-Thionville","startDate":"2016-10-12","conditions":"Pregnancy","enrollment":55},{"nctId":"NCT03897153","phase":"NA","title":"Evaluation of the SONAS® Ultrasound Device for the Assessment of Bilateral Cerebral Perfusion in Subjects With Acute Stroke","status":"UNKNOWN","sponsor":"Burl Concepts, Inc.","startDate":"2019-02-12","conditions":"Stroke, Acute","enrollment":20},{"nctId":"NCT03744130","phase":"NA","title":"Contrast-enhanced Bowel Ultrasound in Making a Diagnosis and Follow-up of Patients With Inflammatory Bowel Disease","status":"UNKNOWN","sponsor":"State Scientific Centre of Coloproctology, Russian Federation","startDate":"2018-01-10","conditions":"Inflammatory Bowel Disease","enrollment":200},{"nctId":"NCT03335566","phase":"PHASE3","title":"An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2014-05-11","conditions":"Liver Lesions","enrollment":424},{"nctId":"NCT02295449","phase":"NA","title":"Quantitative Prostate Cancer Contrast-enhanced Ultrasound","status":"UNKNOWN","sponsor":"Hospices Civils de Lyon","startDate":"2015-06-09","conditions":"Prostate Cancer","enrollment":130},{"nctId":"NCT00829413","phase":"PHASE3","title":"SonoVue®-Enhanced Ultrasound (US) Versus Unenhanced US for Focal Liver Lesion Characterization","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2010-06","conditions":"Liver Neoplasms","enrollment":353},{"nctId":"NCT02786810","phase":"PHASE2","title":"Contrast Enhanced Ultrasound for Evaluation of Reflux Nephropathy","status":"COMPLETED","sponsor":"University of Tennessee","startDate":"2016-03","conditions":"Urinary Tract Infection, Vesicoureteral Reflux","enrollment":10},{"nctId":"NCT03115242","phase":"NA","title":"Contrast Enhanced Ultrasound of Carotid Plaque in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Versailles Hospital","startDate":"2015-08","conditions":"Cerebral Infarction","enrollment":35},{"nctId":"NCT03385200","phase":"PHASE3","title":"KVUS at Neoadjuvant CTx of Breast Cancer","status":"UNKNOWN","sponsor":"RWTH Aachen University","startDate":"2016-12-12","conditions":"Early Primary Breast Cancer","enrollment":60},{"nctId":"NCT00788697","phase":"PHASE3","title":"SonoVue®-Enhanced Ultrasound Versus Unenhanced US for Focal Liver Lesion Characterization","status":"COMPLETED","sponsor":"Bracco Diagnostics, Inc","startDate":"2009-09","conditions":"Liver Neoplasms","enrollment":349},{"nctId":"NCT00489697","phase":"NA","title":"Evaluation of Contrast-enhanced Ultrasound Imaging for the Early Estimate of Bevacizumab Effect on Colorectal Cancer Liver Metastases","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2007-01","conditions":"Metastatic Colorectal Cancer","enrollment":200},{"nctId":"NCT02457390","phase":"NA","title":"The Value of CE-LUS During Robot-assisted Surgery for Primary Colorectal Cancer","status":"COMPLETED","sponsor":"Odense University Hospital","startDate":"2015-01","conditions":"Colorectal Cancer","enrollment":50},{"nctId":"NCT01765036","phase":"NA","title":"Contrast-harmonic Endoscopic Ultrasound (CH-EUS) for the Diagnosis of Pancreatic Adenocarcinoma","status":"COMPLETED","sponsor":"Société Française d'Endoscopie Digestive","startDate":"2009-07","conditions":"Pancreatic Adenocarcinoma","enrollment":100},{"nctId":"NCT01526200","phase":"","title":"Contrast-Enhanced Intraoperative Ultrasound During Liver Surgery for Colorectal Cancer Liver Metastases","status":"COMPLETED","sponsor":"University of Milan","startDate":"2007-10","conditions":"Colon Cancer Liver Metastasis","enrollment":127},{"nctId":"NCT01471912","phase":"NA","title":"Elongation of Foveal Tissue After Macular Hole Surgery","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2009-09","conditions":"Macular Holes","enrollment":31}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1328,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["sulfur hexafluoride microbubbles","SonoVue sulphur hexafluoride microbubbles 8 microlitres/ml","Powder and solvent for dispersion for injection.","MARKETING AUTHORISATION NUMBER(S): EU/1/01/177/002","sulfur hexafluoride lipid-type A microspheres"],"phase":"phase_3","status":"active","brandName":"SonoVue®","genericName":"SonoVue®","companyName":"GE Healthcare","companyId":"ge-healthcare","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SonoVue is a microbubble ultrasound contrast agent that enhances ultrasound imaging. Used for Enhanced ultrasound imaging of the liver, spleen, and other organs.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}