{"id":"sonidegib-phosphate-capsules","safety":{"commonSideEffects":[{"rate":"60–70","effect":"Muscle spasms"},{"rate":"40–50","effect":"Alopecia"},{"rate":"30–40","effect":"Dysgeusia (taste disturbance)"},{"rate":"25–35","effect":"Fatigue"},{"rate":"20–30","effect":"Nausea"},{"rate":"15–25","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL3137317","moleculeType":"Small molecule","molecularWeight":"681.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sonidegib selectively inhibits Smoothened, a key transmembrane protein in the Hedgehog signaling cascade. By blocking SMO, it prevents downstream activation of Gli transcription factors, thereby suppressing the proliferation of cells dependent on Hedgehog pathway signaling. This mechanism is particularly effective in tumors with constitutive Hedgehog pathway activation, such as basal cell carcinoma.","oneSentence":"Sonidegib is a Hedgehog pathway inhibitor that blocks Smoothened (SMO) signaling to suppress aberrant cell proliferation driven by Hedgehog pathway activation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:46.972Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Locally advanced basal cell carcinoma (laBCC)"}]},"trialDetails":[{"nctId":"NCT06880848","phase":"PHASE4","title":"Sonidegib in Adult Patients With Locally Advanced Basal Cell Carcinoma (laBCC) in China","status":"COMPLETED","sponsor":"Jemincare","startDate":"2023-06-21","conditions":"Carcinoma, Basal Cell (BCC)","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sonidegib Phosphate Capsules","genericName":"Sonidegib Phosphate Capsules","companyName":"Jemincare","companyId":"jemincare","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sonidegib Phosphate Capsules are used to treat locally advanced basal cell carcinoma (BCC). They work by inhibiting the protein smoothened, a component of the Hedgehog signaling pathway.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}