{"id":"sonazoid-and-sonovue","safety":{"commonSideEffects":[{"rate":"null","effect":"Allergic reactions"},{"rate":"null","effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"They contain perflutren lipid microspheres that reflect sound waves, allowing for improved visualization of blood flow and tissue structure during ultrasound imaging. This can be particularly useful in procedures such as liver and kidney imaging.","oneSentence":"Sonazoid and Sonovue are ultrasound contrast agents that work by enhancing the contrast of ultrasound images through the use of microbubbles.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:31.555Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver imaging"},{"name":"Kidney imaging"}]},"trialDetails":[{"nctId":"NCT07145801","phase":"PHASE2","title":"Y-90 Treatment Response Using Transarterial Radioembolization","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2025-09-11","conditions":"HCC, Hepatocellular Carcinoma, Liver Cancer","enrollment":30},{"nctId":"NCT07155954","phase":"","title":"Value of Super-resolution Ultrasonography in Differentiating Benign and Malignant Lymph Nodes","status":"RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2024-10-23","conditions":"Lymphadenopathy, Lymphnode Metastasis, Lymphoma","enrollment":779},{"nctId":"NCT04720456","phase":"PHASE2","title":"SHAPE of Portal Hypertension in Children","status":"RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2021-11-03","conditions":"Hypertension, Portal","enrollment":120},{"nctId":"NCT04006275","phase":"PHASE3","title":"Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2019-06-30","conditions":"Hepatocellular Carcinoma, Cirrhosis","enrollment":100},{"nctId":"NCT03335566","phase":"PHASE3","title":"An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2014-05-11","conditions":"Liver Lesions","enrollment":424},{"nctId":"NCT01526200","phase":"","title":"Contrast-Enhanced Intraoperative Ultrasound During Liver Surgery for Colorectal Cancer Liver Metastases","status":"COMPLETED","sponsor":"University of Milan","startDate":"2007-10","conditions":"Colon Cancer Liver Metastasis","enrollment":127}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":56,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Sonazoid and Sonovue","genericName":"Sonazoid and Sonovue","companyName":"Second Affiliated Hospital, School of Medicine, Zhejiang University","companyId":"second-affiliated-hospital-school-of-medicine-zhejiang-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sonazoid and Sonovue are small molecule contrast agents used in contrast-enhanced ultrasound (CEUS) imaging. They are studied for various conditions, including Hepatocellular Carcinoma, Cirrhosis, Lymphadenopathy, Lymphnode Metastasis, and Lymphoma, with indications such as evaluating liver lesions and lymph nodes before surgery or biopsy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}