{"id":"solriamfetol-oral-tablet-sunosi","safety":{"commonSideEffects":[{"rate":"15-20","effect":"Headache"},{"rate":"10-15","effect":"Insomnia"},{"rate":"8-12","effect":"Nausea"},{"rate":"5-10","effect":"Anxiety"},{"rate":"5-8","effect":"Increased heart rate"},{"rate":"5-8","effect":"Dry mouth"}]},"_chembl":{"chemblId":"CHEMBL4297620","moleculeType":"Small molecule","molecularWeight":"194.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Solriamfetol works by inhibiting the reuptake of dopamine and norepinephrine, thereby increasing their concentrations in the synaptic space and enhancing neural signaling associated with wakefulness and alertness. This mechanism promotes arousal and reduces excessive daytime sleepiness in patients with narcolepsy and obstructive sleep apnea.","oneSentence":"Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that increases wakefulness by blocking the reuptake of these neurotransmitters in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:45.102Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Excessive daytime sleepiness in patients with narcolepsy"},{"name":"Excessive daytime sleepiness in patients with obstructive sleep apnea"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sunosi"],"phase":"marketed","status":"active","brandName":"Solriamfetol Oral Tablet [Sunosi]","genericName":"Solriamfetol Oral Tablet [Sunosi]","companyName":"Rochester Center for Behavioral Medicine","companyId":"rochester-center-for-behavioral-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that increases wakefulness by blocking the reuptake of these neurotransmitters in the central nervous system. Used for Excessive daytime sleepiness in patients with narcolepsy, Excessive daytime sleepiness in patients with obstructive sleep apnea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}