{"id":"sofosbuvir-ledipasvir-plus-ribavirin-12w","safety":{"commonSideEffects":[{"rate":"null","effect":"Fatigue"},{"rate":"null","effect":"Headache"},{"rate":"null","effect":"Nausea"},{"rate":"null","effect":"Diarrhea"},{"rate":"null","effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sofosbuvir is a nucleotide analog inhibitor of the HCV NS5B polymerase, while Ledipasvir is a NS5A inhibitor. Ribavirin is an antiviral medication that works by inhibiting the HCV RNA-dependent RNA polymerase. The combination of these three drugs leads to a synergistic effect, resulting in the suppression of viral replication and the clearance of the virus from the body.","oneSentence":"Sofosbuvir/Ledipasvir plus Ribavirin works by inhibiting the HCV NS5B polymerase and NS5A protein, and also inhibiting the HCV RNA-dependent RNA polymerase, leading to the suppression of viral replication.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:23.341Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis C virus (HCV) infection"},{"name":"Genotype 1, 2, 3, 4, 5, or 6 HCV infection"}]},"trialDetails":[{"nctId":"NCT03061032","phase":"PHASE3","title":"Treatment of Hepatitis C Virus Infection With Generic Sofosbuvir/Ledipasvir in Iranian Patients","status":"UNKNOWN","sponsor":"Iran Hepatitis Network","startDate":"2017-03","conditions":"Hepatitis C","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Sofosbuvir/Ledipasvir plus Ribavirin 12W","genericName":"Sofosbuvir/Ledipasvir plus Ribavirin 12W","companyName":"Iran Hepatitis Network","companyId":"iran-hepatitis-network","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sofosbuvir/Ledipasvir plus Ribavirin works by inhibiting the HCV NS5B polymerase and NS5A protein, and also inhibiting the HCV RNA-dependent RNA polymerase, leading to the suppression of viral replication. Used for Chronic hepatitis C virus (HCV) infection, Genotype 1, 2, 3, 4, 5, or 6 HCV infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}