{"id":"sofosbuvir-ledipasvir-12w","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Fatigue"},{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL2374220","moleculeType":"Small molecule","molecularWeight":"889.02"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sofosbuvir works by inhibiting the NS5B polymerase enzyme, which is essential for the replication of the hepatitis C virus. Ledipasvir targets the NS5A protein, which plays a critical role in the viral life cycle. By inhibiting these two proteins, Sofosbuvir/Ledipasvir 12W prevents the replication of the hepatitis C virus.","oneSentence":"Sofosbuvir/Ledipasvir 12W is a combination of a nucleotide analog inhibitor of the hepatitis C virus NS5B polymerase and a potent inhibitor of the hepatitis C virus NS5A protein.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:08.667Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis C virus infection"}]},"trialDetails":[{"nctId":"NCT03061032","phase":"PHASE3","title":"Treatment of Hepatitis C Virus Infection With Generic Sofosbuvir/Ledipasvir in Iranian Patients","status":"UNKNOWN","sponsor":"Iran Hepatitis Network","startDate":"2017-03","conditions":"Hepatitis C","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Sofosbuvir/Ledipasvir 12W","genericName":"Sofosbuvir/Ledipasvir 12W","companyName":"Iran Hepatitis Network","companyId":"iran-hepatitis-network","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sofosbuvir/Ledipasvir 12W is a combination of a nucleotide analog inhibitor of the hepatitis C virus NS5B polymerase and a potent inhibitor of the hepatitis C virus NS5A protein. Used for Chronic hepatitis C virus infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}