{"id":"sodium-perborate","rwe":[],"tags":[{"label":"sodium perborate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A01AB19","category":"atc"},{"label":"Oral","category":"route"},{"label":"Topical","category":"route"},{"label":"Powder","category":"form"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"safetySignals":[{"llr":212.156,"date":"","count":46,"signal":"Gastrointestinal toxicity","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=212)"},{"llr":197.602,"date":"","count":46,"signal":"Pulmonary toxicity","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=198)"},{"llr":161.109,"date":"","count":46,"signal":"Joint injury","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=161)"},{"llr":147.62,"date":"","count":46,"signal":"Neoplasm malignant","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=148)"},{"llr":146.459,"date":"","count":46,"signal":"Joint stiffness","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=146)"},{"llr":138.644,"date":"","count":46,"signal":"Hepatotoxicity","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=139)"},{"llr":127.603,"date":"","count":42,"signal":"C-reactive protein abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 42 times (LLR=128)"},{"llr":110.937,"date":"","count":46,"signal":"Therapy non-responder","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=111)"},{"llr":109.557,"date":"","count":46,"signal":"Musculoskeletal pain","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=110)"},{"llr":92.079,"date":"","count":46,"signal":"Therapeutic product effect incomplete","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=92)"}],"commonSideEffects":[{"effect":"Gastrointestinal toxicity","drugRate":"LLR 212","severity":"common"},{"effect":"Pulmonary toxicity","drugRate":"LLR 198","severity":"common"},{"effect":"Joint injury","drugRate":"LLR 161","severity":"common"},{"effect":"Neoplasm malignant","drugRate":"LLR 148","severity":"common"},{"effect":"Joint stiffness","drugRate":"LLR 146","severity":"common"},{"effect":"Hepatotoxicity","drugRate":"LLR 139","severity":"common"},{"effect":"C-reactive protein abnormal","drugRate":"LLR 128","severity":"common"},{"effect":"Therapy non-responder","drugRate":"LLR 111","severity":"common"},{"effect":"Musculoskeletal pain","drugRate":"LLR 110","severity":"common"},{"effect":"Therapeutic product effect incomplete","drugRate":"LLR 92","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["sodium perborate","sodium perborate monohydrate"],"offLabel":[],"synonyms":["sodium perborate","sodium perborate monohydrate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"sodium perborate","explanation":"Think of it like a strong cleaning agent that helps kill germs and bacteria. When sodium perborate is present, it breaks down into hydrogen peroxide, which then helps to destroy the outer membranes of microorganisms, ultimately killing them. This process is similar to how bleach works to sanitize surfaces.","oneSentence":"Sodium perborate works by releasing hydrogen peroxide, which is thought to have antimicrobial properties.","technicalDetail":"Sodium perborate is a peroxygen compound that releases hydrogen peroxide (H2O2) through hydrolysis, which is thought to be responsible for its antimicrobial activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4777","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=sodium%20perborate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=sodium perborate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:40:50.350710","biosimilars":[],"competitors":[{"drugName":"hydrogen peroxide","drugSlug":"hydrogen-peroxide","fdaApproval":"","patentExpiry":"Jul 4, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"amphotericin B","drugSlug":"amphotericin-b","fdaApproval":"1964-11-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyquinoline","drugSlug":"oxyquinoline","fdaApproval":"","relationship":"same-class"},{"drugName":"neomycin","drugSlug":"neomycin","fdaApproval":"1957-03-26","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"natamycin","drugSlug":"natamycin","fdaApproval":"1978-10-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tetracycline","drugSlug":"tetracycline","fdaApproval":"1953-11-19","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metronidazole","drugSlug":"metronidazole","fdaApproval":"1963-07-18","patentExpiry":"Oct 4, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"doxycycline","drugSlug":"doxycycline","fdaApproval":"1967-12-05","patentExpiry":"Dec 19, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"minocycline","drugSlug":"minocycline","fdaApproval":"1971-06-30","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"sodium perborate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrogen-peroxide","brandName":"hydrogen peroxide","genericName":"hydrogen peroxide","approvalYear":"","relationship":"same-class"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"},{"drugId":"amphotericin-b","brandName":"amphotericin B","genericName":"amphotericin B","approvalYear":"1964","relationship":"same-class"},{"drugId":"oxyquinoline","brandName":"oxyquinoline","genericName":"oxyquinoline","approvalYear":"","relationship":"same-class"},{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"},{"drugId":"miconazole","brandName":"miconazole","genericName":"miconazole","approvalYear":"1974","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"metronidazole","brandName":"metronidazole","genericName":"metronidazole","approvalYear":"1963","relationship":"same-class"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06782087","phase":"PHASE1","title":"A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent","status":"ENROLLING_BY_INVITATION","sponsor":"Misr University for Science and Technology","startDate":"2025-10-15","conditions":["Tooth Discoloration"],"enrollment":42,"completionDate":"2025-10-30"},{"nctId":"NCT06503029","phase":"PHASE4","title":"Evaluate Cytotoxicity, Leaching, and Structural Conformation of Clear Aligners","status":"NOT_YET_RECRUITING","sponsor":"Riyadh Elm University","startDate":"2024-07-15","conditions":["Malocclusion","Cytotoxicity"],"enrollment":84,"completionDate":"2025-03-05"},{"nctId":"NCT05921500","phase":"NA","title":"Clinical and Radiographic Evaluation of Intra Coronal Bleaching of Primary Anterior Teeth","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2022-05-01","conditions":["Dental Trauma"],"enrollment":13,"completionDate":"2023-08-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral, Topical","formulation":"Powder","formulations":[{"form":"POWDER, FOR SOLUTION","route":"ORAL","productName":"Amosan Wound CleanserCherry Flavour"},{"form":"POWDER, FOR SOLUTION","route":"TOPICAL","productName":"Amosan Oral Wound Cleanser"}]},"crossReferences":{"NUI":"N0000148205","MMSL":"NOCODE","NDDF":"003159","UNII":"Y52BK1W96C","VUID":"4020415","CHEBI":"CHEBI:30178","VANDF":"4020415","RXNORM":"1991500","UMLSCUI":"C0074750","ChEMBL_ID":"CHEMBL3707333","KEGG_DRUG":"D07066","PUBCHEM_CID":"517072","SNOMEDCT_US":"387434009","SECONDARY_CAS_RN":"7632-04-4","MESH_SUPPLEMENTAL_RECORD_UI":"C027707"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":346,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"A01AB19","allCodes":["A01AB19"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"sodium perborate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Sodium perborate is a small molecule with the chemical formula [Na+]2[B2O4(OH)4]2−(H2O)x, commonly encountered in anhydrous and hexahydrate forms. It has been studied in various clinical trials for conditions such as malocclusion, cytotoxicity, dental trauma, and tooth discoloration, often in combination with products like Invisalign Cleaning Crystals, Fittey Dent Cleaning Tablet, and Listeren Mouthwash.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}