{"id":"sodium-oxybate-smo","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Nausea"},{"rate":"10-20","effect":"Dizziness"},{"rate":"10-15","effect":"Headache"},{"rate":"5-15","effect":"Vomiting"},{"rate":"5-10","effect":"Tremor"},{"rate":"5-10","effect":"Confusion"},{"rate":"5-10","effect":"Enuresis"}]},"_chembl":{"chemblId":"CHEMBL1200682","moleculeType":"Small molecule","molecularWeight":"126.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium oxybate is the sodium salt of gamma-hydroxybutyrate (GHB), which crosses the blood-brain barrier and acts on GABA-B receptors in the central nervous system. It enhances slow-wave sleep architecture and reduces cataplexy and daytime sleepiness in narcolepsy patients. The drug also has effects on sleep-wake cycle regulation through multiple CNS pathways.","oneSentence":"Sodium oxybate is a central nervous system depressant that acts as a GABA-B receptor agonist and GHB (gamma-hydroxybutyrate) precursor to promote sleep and reduce excessive daytime sleepiness.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:41.441Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Narcolepsy with cataplexy"},{"name":"Excessive daytime sleepiness in narcolepsy"}]},"trialDetails":[{"nctId":"NCT02090504","phase":"PHASE4","title":"Comparative Study of Gamma-hydroxy Butyrate Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome","status":"COMPLETED","sponsor":"Catholic University of the Sacred Heart","startDate":"2002-02","conditions":"Alcohol Withdrawal Syndrome, Alcohol Dependence","enrollment":127}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Gamma-hydroxy butyrate (GHB)"],"phase":"marketed","status":"active","brandName":"Sodium Oxybate (SMO)","genericName":"Sodium Oxybate (SMO)","companyName":"Catholic University of the Sacred Heart","companyId":"catholic-university-of-the-sacred-heart","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium oxybate is a central nervous system depressant that acts as a GABA-B receptor agonist and GHB (gamma-hydroxybutyrate) precursor to promote sleep and reduce excessive daytime sleepiness. Used for Narcolepsy with cataplexy, Excessive daytime sleepiness in narcolepsy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}