{"id":"sodium-hypochlorite-5-25","safety":{"commonSideEffects":[{"rate":null,"effect":"Tissue irritation or burning sensation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Bleaching of fabrics or discoloration"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Sodium hypochlorite is a non-selective oxidizing agent that generates hypochlorous acid (HOCl) in aqueous solution. This highly reactive species penetrates microbial cell walls and membranes, oxidizing essential proteins, lipids, and nucleic acids, leading to rapid cell death. It is effective against a wide range of bacteria, viruses, fungi, and spores, making it a potent disinfectant and antiseptic.","oneSentence":"Sodium hypochlorite releases hypochlorous acid, which oxidizes and denatures bacterial and viral proteins, disrupting cell membranes and nucleic acids to exert broad-spectrum antimicrobial activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:35:13.832Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound irrigation and disinfection"},{"name":"Oral rinse for oral hygiene and infection control"},{"name":"Surface disinfection"}]},"trialDetails":[{"nctId":"NCT07453160","phase":"NA","title":"Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment","status":"NOT_YET_RECRUITING","sponsor":"College of Physicians and Surgeons Pakistan","startDate":"2026-02-15","conditions":"Postoperative Pain","enrollment":90},{"nctId":"NCT07163975","phase":"NA","title":"Complete Pulpotomy and Root Canal Treatment Patients With Irreversible Pulpitis With Type 2 Diabetes Mellitus","status":"RECRUITING","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2025-05-01","conditions":"Type 2 Diabetes Mellitus (T2DM), Irreversible Pulpitis","enrollment":106},{"nctId":"NCT07162077","phase":"NA","title":"Etch-bleach-seal Technique in Managing Opacities Related MIH Using Icon®","status":"RECRUITING","sponsor":"Tishreen University","startDate":"2025-08-25","conditions":"Molar Incisor Hypomineralisation","enrollment":24},{"nctId":"NCT07136051","phase":"NA","title":"Evaluation of the Survival of Fissure Sealants Applied With Different Pretreatment Methods on Permanent First Molars: A One-Year Follow-Up","status":"ACTIVE_NOT_RECRUITING","sponsor":"Handan Vural","startDate":"2025-08-03","conditions":"Fissure Sealant, Deproteinization, Bonding Agent","enrollment":40},{"nctId":"NCT07033247","phase":"NA","title":"The Effect of Different Sodium Hypochlorite Concentrations and Activation Techniques on Postoperative Pain","status":"COMPLETED","sponsor":"Cukurova University","startDate":"2024-12-11","conditions":"Chronic Apical Periodontitis","enrollment":120},{"nctId":"NCT07003958","phase":"NA","title":"The Effect of Different Deproteinizing Agents on the Clinical Success of Fissure Sealants in Primary Teeth","status":"RECRUITING","sponsor":"Tokat Gaziosmanpasa University","startDate":"2024-08-05","conditions":"Fissure Sealant","enrollment":60},{"nctId":"NCT06988098","phase":"NA","title":"The Effect of Different Deproteinising Agents on the Clinical Success of Fissure Sealants in Permanent Teeth","status":"RECRUITING","sponsor":"Tokat Gaziosmanpasa University","startDate":"2024-08-01","conditions":"Fissure Sealant","enrollment":60},{"nctId":"NCT06467643","phase":"NA","title":"Minimally Invasive Root Canal Treatment With Active Disinfection on Single Rooted Teeth With Periapical Lesions","status":"COMPLETED","sponsor":"Saint-Joseph University","startDate":"2023-07-07","conditions":"Radiographic Healing of Periapical Lesions Following Ultrasonic Activation of Heated Sodium Hypochlorite Without Instrumentation of Root Canals","enrollment":19},{"nctId":"NCT05841290","phase":"NA","title":"The Incidence of Postoperative Pain After Using Different Types of Sealers","status":"RECRUITING","sponsor":"British University In Egypt","startDate":"2022-08-01","conditions":"Post Operative Pain, Root Canal Sealers, Sillicon Based Sealers","enrollment":50},{"nctId":"NCT05974748","phase":"PHASE3","title":"Role of Propolis Endodontic Irrigant on Post-Operative Pain","status":"COMPLETED","sponsor":"Dow University of Health Sciences","startDate":"2023-04-01","conditions":"Post-operative Pain, Symptomatic Irreversible Pulpitis","enrollment":44},{"nctId":"NCT03635515","phase":"NA","title":"Occurrence of Post-op Pain Following Gentlewave","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2018-09-01","conditions":"Root Canal Infection, Endodontic Disease, Endodontic Inflammation","enrollment":87},{"nctId":"NCT04654845","phase":"NA","title":"Patient Perception Between Two Emergency Treatments of Symptomatic Irreversible Pulpitis.","status":"COMPLETED","sponsor":"Aula Dental Avanzada","startDate":"2020-11-16","conditions":"Irreversible Pulpitis","enrollment":80},{"nctId":"NCT05361278","phase":"NA","title":"Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2021-01-15","conditions":"Dental Caries, Infection, Bacterial, Tooth, Deciduous","enrollment":15},{"nctId":"NCT05339503","phase":"NA","title":"This is the Comparison of Clinical Effectiveness of Hydrochloric Acid-pumice Compound and Sodium Hypochlorite-pumice Compound Used in Microabrasion Technique for the Treatment of Dental Fluorosis. Change in Tooth Shade Was Checked Before and After the Procedure.","status":"COMPLETED","sponsor":"Fatima Jinnah Dental College","startDate":"2019-11-01","conditions":"Dental Fluoroses","enrollment":60},{"nctId":"NCT05299489","phase":"NA","title":"Evaluation Direct and Indirect Composite Restoration in Hypomineralization Molars.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2020-10-15","conditions":"Dental Enamel Hypoplasia, Dental Caries","enrollment":20},{"nctId":"NCT05277246","phase":"NA","title":"Effect of Using Different Concentrations of NaOCI on IL-8 Level","status":"UNKNOWN","sponsor":"Yuzuncu Yil University","startDate":"2022-03-20","conditions":"Irreversible Pulpitis","enrollment":84},{"nctId":"NCT04945382","phase":"NA","title":"Retention of a Flowable Resin-based Sealant With Two Types of Adhesives","status":"UNKNOWN","sponsor":"National University of San Marcos, Peru","startDate":"2021-06","conditions":"Caries,Dental, Pit and Fissure Caries, Sealant Dental","enrollment":50},{"nctId":"NCT04035070","phase":"PHASE4","title":"Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-01","conditions":"Necrotic Pulp","enrollment":51},{"nctId":"NCT04250519","phase":"PHASE1","title":"Evaluation of Post Operative Pain in Retreatment of Molars Using Different Irrigant","status":"UNKNOWN","sponsor":"Tamil Nadu Dr.M.G.R.Medical University","startDate":"2020-02-03","conditions":"Root Canal Infection","enrollment":150},{"nctId":"NCT04190355","phase":"NA","title":"The Effect of Irrigant Types Used During Endodontic Treatment on Postoperative Pain","status":"UNKNOWN","sponsor":"Yuzuncu Yil University","startDate":"2019-09-29","conditions":"Postoperative Pain","enrollment":104},{"nctId":"NCT03795636","phase":"NA","title":"Allium Sativum Extract as an Irrigant","status":"COMPLETED","sponsor":"Minia University","startDate":"2016-10-30","conditions":"Infected Root Canals of Primary Molars","enrollment":91},{"nctId":"NCT03792217","phase":"NA","title":"Postoperative Pain After Endodontic Irrigation Using 1.3% Versus 5.25% Sodium Hypochlorite","status":"COMPLETED","sponsor":"Cairo University","startDate":"2011-07","conditions":"Dental Pulp Necrosis","enrollment":308}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NaOCl"],"phase":"phase_3","status":"active","brandName":"Sodium hypochlorite 5.25%","genericName":"Sodium hypochlorite 5.25%","companyName":"Dow University of Health Sciences","companyId":"dow-university-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium hypochlorite 5.25% is a small molecule used as an endodontic irrigant, studied for its effects on post-operative pain, symptomatic irreversible pulpitis, caries, and other dental conditions. It is also known by various synonyms, including household bleach and Dakin's solution.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}