{"id":"sodium-glycerophosphate","rwe":[{"pmid":"41405614","year":"2025","title":"[Severe Hypophosphatemia Treated with Intravenous Phosphate: A Case Report].","finding":"","journal":"Revista medica de Chile","studyType":"Clinical Study"},{"pmid":"41242387","year":"2025","title":"The efficacy and safety of diluted oral phosphate enema versus intravenous sodium glycerophosphate in the treatment of hypophosphatemia in intensive care unit patients - A non-inferiority trial.","finding":"","journal":"Clinical nutrition ESPEN","studyType":"Clinical Study"},{"pmid":"40545092","year":"2025","title":"Design and properties of cyclodextrin grafted chitosan/sodium alginate dual-network hydrogel based on physical cross-linking.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"40289904","year":"2025","title":"Erythropoietin-Stimulated Macrophage-Derived Extracellular Vesicles in Chitosan Hydrogel Rescue BMSCs Fate by Targeting EGFR to Alleviate Inflammatory Bone Loss in Periodontitis.","finding":"","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","studyType":"Clinical Study"},{"pmid":"40233907","year":"2025","title":"A thermosensitive chitosan hydrogel loaded with Thonningianin A nanoparticles promotes diabetic wound healing by modulating oxidative stress and angiogenesis.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"B05XA14","category":"atc"},{"label":"Intravenous","category":"route"},{"label":"Injection","category":"form"},{"label":"Active","category":"status"},{"label":"Hypophosphatemia","category":"indication"},{"label":"Fresenius Kabi Usa","category":"company"},{"label":"Approved 2010s","category":"decade"}],"phase":"marketed","safety":{"safetySignals":[{"llr":69.109,"date":"","count":10,"signal":"Neonatal infection","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=69)"},{"llr":61.729,"date":"","count":15,"signal":"Foetal growth restriction","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=62)"},{"llr":56.723,"date":"","count":7,"signal":"Pantoea agglomerans infection","source":"DrugCentral FAERS","actionTaken":"Reported 7 times (LLR=57)"},{"llr":56.568,"date":"","count":13,"signal":"Product preparation error","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=57)"}],"commonSideEffects":[],"specialPopulations":{"Pregnancy":"The limited available data on the use of KABIVEN (R) in pregnant women are not sufficient to inform drug-associated risk. However, there are clinical considerations if KABIVEN (R) is used in pregnant women. Severe malnutrition in pregnant woman is associated with preterm delivery, low birth weight, intrauterine growth restriction, congenital malformations and perinatal mortality. Parenteral nutrition should be considered if pregnant womans nutritional requirements cannot be fulfilled by oral or enteral intake.","Geriatric use":"Clinical studies of KABIVEN (R) did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from other younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant diseases or other drug therapy.","Paediatric use":"The safety and effectiveness of KABIVEN (R) in pediatric patients has not been established. Deaths in preterm infants after infusion of intravenous lipid emulsion have been reported. Patients, particularly preterm infants, are at risk for aluminum toxicity. KABIVEN (R) is not recommended for use in pediatric patients under the age of two years, including preterm infants, as the fixed content of the formulation may not provide adequate nutrition for this age group.","Renal impairment":"Patients on dialysis or continuous renal replacement therapy may require additional protein supplementation to meet nutritional requirements. If required, adjust the volume of KABIVEN (R) administered based on serum electrolyte levels and fluid balance."}},"trials":[],"aliases":[],"company":"Fresenius Kabi","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=SODIUM GLYCEROPHOSPHATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:24:54.682817+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T00:25:14.940477+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:25:01.585272+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SODIUM GLYCEROPHOSPHATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:25:02.369729+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL6067979/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:25:03.524525+00:00"}},"allNames":"perikabiven in plastic container","offLabel":[],"synonyms":["sodium glycerophosphate pentahydrate","sodium glycerophosphate anhydrous","glycophos","sodium glycerophosphate"],"timeline":[{"date":"2014-08-25","type":"positive","source":"DrugCentral","milestone":"FDA approval (Fresenius Kabi Usa)"}],"aiSummary":"Sodium Glycerophosphate, marketed as Perikabiven by Fresenius Kabi, is a phosphate replenishment therapy primarily indicated for hypophosphatemia. Its key strength lies in its patented composition, which is protected until 2028, providing a competitive edge over off-patent alternatives like sodium bicarbonate and sodium chloride. The primary risk is the presence of multiple generic competitors in the same class, such as magnesium sulfate and ammonium chloride, which could erode market share.","approvals":[{"date":"2014-08-25","orphan":false,"company":"FRESENIUS KABI USA","regulator":"FDA"}],"brandName":"Perikabiven In Plastic Container","ecosystem":[{"indication":"Hypophosphatemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"sodium phosphate, monobasic","slug":"sodium-phosphate,-monobasic","company":""},{"name":"sodium phosphate, monobasic, monohydrate","slug":"sodium-phosphate,-monobasic,-monohydrate","company":"Salix Pharms"}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Sodium glycerophosphate is a small molecule that acts as a phosphate supplement, increasing phosphate levels in the body to treat hypophosphatemia."},"commercial":{"launchDate":"2014","_launchSource":"DrugCentral (FDA 2014-08-25, FRESENIUS KABI USA)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1318","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=SODIUM%20GLYCEROPHOSPHATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SODIUM GLYCEROPHOSPHATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:40:31.882729","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:25:14.940906+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"potassium chloride","drugSlug":"potassium-chloride","fdaApproval":"1965-12-16","patentExpiry":"Mar 7, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sodium bicarbonate","drugSlug":"sodium-bicarbonate","fdaApproval":"1981-10-28","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sodium chloride","drugSlug":"sodium-chloride","fdaApproval":"1965-12-16","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ammonium chloride","drugSlug":"ammonium-chloride","fdaApproval":"1978-10-13","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"magnesium sulfate","drugSlug":"magnesium-sulfate","fdaApproval":"1981-10-06","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"calcium chloride","drugSlug":"calcium-chloride","fdaApproval":"1971-03-22","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sodium acetate","drugSlug":"sodium-acetate","fdaApproval":"1983-05-04","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sodium phosphate","drugSlug":"sodium-phosphate","fdaApproval":"1983-05-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"magnesium chloride","drugSlug":"magnesium-chloride","fdaApproval":"1975-08-13","relationship":"same-class"},{"drugName":"zinc chloride","drugSlug":"zinc-chloride","fdaApproval":"1986-06-26","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"potassium lactate","drugSlug":"potassium-lactate","fdaApproval":"1986-05-08","relationship":"same-class"},{"drugName":"potassium acetate","drugSlug":"potassium-acetate","fdaApproval":"1971-09-24","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"zinc sulfate","drugSlug":"zinc-sulfate","fdaApproval":"1987-05-05","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"sodium glycerophosphate","indications":{"approved":[{"name":"Hypophosphatemia","source":"DrugCentral","snomedId":4996001,"regulator":"FDA","eligibility":null}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"potassium-chloride","brandName":"potassium chloride","genericName":"potassium chloride","approvalYear":"1965","relationship":"same-class"},{"drugId":"sodium-bicarbonate","brandName":"sodium bicarbonate","genericName":"sodium bicarbonate","approvalYear":"1981","relationship":"same-class"},{"drugId":"sodium-chloride","brandName":"sodium chloride","genericName":"sodium chloride","approvalYear":"1965","relationship":"same-class"},{"drugId":"ammonium-chloride","brandName":"ammonium chloride","genericName":"ammonium chloride","approvalYear":"1978","relationship":"same-class"},{"drugId":"magnesium-sulfate","brandName":"magnesium sulfate","genericName":"magnesium sulfate","approvalYear":"1981","relationship":"same-class"},{"drugId":"calcium-chloride","brandName":"calcium chloride","genericName":"calcium chloride","approvalYear":"1971","relationship":"same-class"},{"drugId":"sodium-acetate","brandName":"sodium acetate","genericName":"sodium acetate","approvalYear":"1983","relationship":"same-class"},{"drugId":"sodium-phosphate","brandName":"sodium phosphate","genericName":"sodium phosphate","approvalYear":"1983","relationship":"same-class"},{"drugId":"magnesium-chloride","brandName":"magnesium chloride","genericName":"magnesium chloride","approvalYear":"1975","relationship":"same-class"},{"drugId":"zinc-chloride","brandName":"zinc chloride","genericName":"zinc chloride","approvalYear":"1986","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05007483","phase":"NA","title":"Efficacy of Diet on Quality of Life in Multiple Sclerosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Terry L. Wahls","startDate":"2022-02-10","conditions":["Multiple Sclerosis, Relapsing-Remitting"],"enrollment":162,"completionDate":"2026-12-01"},{"nctId":"NCT07060859","phase":"NA","title":"Topical Dexamethasone, Ascorbic Acid, and BGP for Enhancing Implant Osseointegration","status":"COMPLETED","sponsor":"Manar Ziad Foura-Matar","startDate":"2023-01-15","conditions":["Implant Stability and Osseointegration"],"enrollment":18,"completionDate":"2023-09-30"},{"nctId":"NCT06842121","phase":"PHASE1","title":"A Bioequivalence Study Comparing Organic Phosphate (Sodium Glycerophosphate Injection) to Inorganic Phosphate (Sodium Phosphates Injection, USP)","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2025-01-27","conditions":["Parenteral Nutrition"],"enrollment":42,"completionDate":"2025-05-22"},{"nctId":"NCT06842134","phase":"PHASE1","title":"A Study Comparing Organic Phosphate (Sodium Glycerophosphate Injection) to Numeta G16%E","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2025-01-27","conditions":["Parenteral Nutrition"],"enrollment":16,"completionDate":"2025-05-22"},{"nctId":"NCT06651892","phase":"PHASE2,PHASE3","title":"The Efficacy and Safety of Diluted Oral Phosphate Enema Versus Intravenous Sodium Glycerophosphate in The Treatment of Hypophosphatemia in ICU Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-05-01","conditions":["Acute Hypophosphatemia"],"enrollment":42,"completionDate":"2024-12-30"},{"nctId":"NCT06754670","phase":"","title":"Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning","status":"RECRUITING","sponsor":"Peking Union Medical College","startDate":"2024-10-01","conditions":["Mechanical Ventilation","Weaning Failure","Hypophosphatemia"],"enrollment":70,"completionDate":"2025-08-01"},{"nctId":"NCT06473792","phase":"NA","title":"Effect of Probiotic Toothpaste and Regular Toothpaste on Plaque Levels of Orthodontic Patients","status":"COMPLETED","sponsor":"Kanza Tahir","startDate":"2024-06-04","conditions":["Plaque"],"enrollment":52,"completionDate":"2024-07-15"},{"nctId":"NCT06135259","phase":"PHASE3","title":"Topical Erythropoietin Hydrogel in Management of Oral Lichen Planus","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-05-20","conditions":["Oral Lichen Planus"],"enrollment":18,"completionDate":"2024-09-23"},{"nctId":"NCT05682846","phase":"NA","title":"Optimization of Serum Phosphorus Level and Weaning From Mechanical Ventilation","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-05-01","conditions":["Mechanical Ventilation"],"enrollment":124,"completionDate":"2023-02-28"},{"nctId":"NCT04519762","phase":"PHASE4","title":"Levels of 'Hypophosphatemia Affect Outcome of Septic Patients in ICU","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2020-09-15","conditions":["Hypophosphatemia"],"enrollment":100,"completionDate":"2020-12-15"},{"nctId":"NCT00875212","phase":"PHASE1","title":"Effect of Calcium Glycerophosphate (CaGP) - Fluoride Dentifrice on Dental Biofilm pH","status":"COMPLETED","sponsor":"Federal University of Paraíba","startDate":"2006-01","conditions":["Dental Caries"],"enrollment":12,"completionDate":"2008-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Intravenous","formulation":"Injection","formulations":[{"form":"INJECTION, EMULSION","route":"INTRAVENOUS","productName":"Kabiven"},{"form":"INJECTION, EMULSION","route":"INTRAVENOUS","productName":"Perikabiven"},{"form":"INJECTION, SOLUTION","route":"INTRAVENOUS","productName":"Glycophos"}]},"crossReferences":{"MMSL":"15422","NDDF":"005907","UNII":"RCS9EQ01V4","VANDF":"4020405","RXNORM":"1423802","UMLSCUI":"C0377349","chemblId":"CHEMBL6067979","ChEMBL_ID":"CHEMBL3039567","KEGG_DRUG":"D10489","DRUGBANK_ID":"DB09561","PUBCHEM_CID":"754","SNOMEDCT_US":"415542004","SECONDARY_CAS_RN":"1334-74-3","MESH_SUPPLEMENTAL_RECORD_UI":"C029620"},"formularyStatus":[],"originalProduct":{"form":"INJECTION, SOLUTION","route":"INTRAVENOUS","company":"Fresenius Kabi USA, LLC","brandName":"Glycophos","isOriginal":true,"marketingStatus":"Unapproved drug for use in drug shortage"},"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"2014-","companyName":"Fresenius Kabi Usa","relationship":"Original Developer"}],"publicationCount":105,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"B05XA14","allCodes":["B05XA14"]},"biosimilarFilings":[],"originalDeveloper":"Fresenius Kabi Usa","recentPublications":[{"date":"2025 Dec","pmid":"41405614","title":"[Severe Hypophosphatemia Treated with Intravenous Phosphate: A Case Report].","journal":"Revista medica de Chile"},{"date":"2025 Dec","pmid":"41242387","title":"The efficacy and safety of diluted oral phosphate enema versus intravenous sodium glycerophosphate in the treatment of hypophosphatemia in intensive care unit patients - A non-inferiority trial.","journal":"Clinical nutrition ESPEN"},{"date":"2025 Aug","pmid":"40545092","title":"Design and properties of cyclodextrin grafted chitosan/sodium alginate dual-network hydrogel based on physical cross-linking.","journal":"International journal of biological macromolecules"},{"date":"2025 Jun","pmid":"40289904","title":"Erythropoietin-Stimulated Macrophage-Derived Extracellular Vesicles in Chitosan Hydrogel Rescue BMSCs Fate by Targeting EGFR to Alleviate Inflammatory Bone Loss in Periodontitis.","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"date":"2025 May","pmid":"40233907","title":"A thermosensitive chitosan hydrogel loaded with Thonningianin A nanoparticles promotes diabetic wound healing by modulating oxidative stress and angiogenesis.","journal":"International journal of biological macromolecules"}],"combinationProducts":[{"brandName":"Kabiven","ingredients":"alanine + arginine + aspartic acid + calcium chloride + glucose + glutamic acid + glycine + histidine + isoleucine + leucine + lysine + magnesium sulfate + methionine + phenylalanine + potassium chloride + proline + serine + sodium acetate + sodium glycerophosphate + threonine + tryptophan + tyrosine + valine"},{"brandName":"Perikabiven","ingredients":"alanine + arginine + aspartic acid + calcium chloride + glucose + glutamic acid + glycine + histidine + isoleucine + leucine + lysine + magnesium sulfate + methionine + phenylalanine + potassium chloride + proline + serine + sodium acetate + sodium glycerophosphate + threonine + tryptophan + tyrosine + valine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"approved","companyName":"Fresenius Kabi","companyId":"fresenius-kabi","modality":"Small Molecule","firstApprovalDate":"2014","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"2014-08-25T00:00:00.000Z","mah":"FRESENIUS KABI USA","brand_name_local":null,"application_number":""},{"country_code":"SA","regulator":"SFDA","status":"likely_approved","approval_date":"2014-08-25T00:00:00.000Z","mah":"FRESENIUS KABI USA","brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":"2014-08-25T00:00:00.000Z","mah":"FRESENIUS KABI USA","brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":"2014-08-25T00:00:00.000Z","mah":"FRESENIUS KABI USA","brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":"2014-08-25T00:00:00.000Z","mah":"FRESENIUS KABI USA","brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":"2014-08-25T00:00:00.000Z","mah":"FRESENIUS KABI USA","brand_name_local":null,"application_number":null},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:25:14.940906+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}