{"id":"sodium-citrate-citratic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Hyperkalemia (in patients with renal impairment)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Citrate acts as a buffer that neutralizes gastric acid in the stomach, reducing acidity. When absorbed, citrate is metabolized to bicarbonate, which increases urinary pH. This alkalinization of urine is used to prevent formation of certain kidney stones (uric acid and cystine stones) and to enhance renal excretion of certain drugs.","oneSentence":"Sodium citrate and citric acid work together to neutralize stomach acid and raise urinary pH, making urine more alkaline.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:08:29.882Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of uric acid kidney stones"},{"name":"Prevention of cystine kidney stones"},{"name":"Alkalinization of urine for management of certain poisonings or drug overdoses"}]},"trialDetails":[{"nctId":"NCT00586131","phase":"PHASE4","title":"Arterial pH and Total Body Nitrogen Balances in APD","status":"COMPLETED","sponsor":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","startDate":"2003-09","conditions":"End-stage Renal Disease","enrollment":8}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2357,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sodium citrate/citratic acid","genericName":"Sodium citrate/citratic acid","companyName":"Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center","companyId":"lundquist-institute-for-biomedical-innovation-at-harbor-ucla-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium citrate and citric acid work together to neutralize stomach acid and raise urinary pH, making urine more alkaline. Used for Prevention of uric acid kidney stones, Prevention of cystine kidney stones, Alkalinization of urine for management of certain poisonings or drug overdoses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}