{"id":"sodium-carboximethycellulose","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild ocular irritation"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Allergic contact dermatitis (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an anionic polysaccharide, sodium carboxymethylcellulose (CMC-Na) forms a hydrophilic gel layer when dissolved in aqueous solutions. It is used topically or as an excipient to protect and lubricate mucous membranes, reduce friction, and maintain moisture. Its mechanism is primarily physical rather than pharmacological, making it suitable for ophthalmic, oral, and gastrointestinal applications.","oneSentence":"Sodium carboxymethylcellulose is a cellulose derivative that acts as a viscous, water-soluble polymer to provide lubrication, moisture retention, and protective coating of mucosal surfaces.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:28.976Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye syndrome (artificial tears)"},{"name":"Oral mucositis protection"},{"name":"Gastrointestinal mucosal protection"}]},"trialDetails":[{"nctId":"NCT00797030","phase":"PHASE4","title":"Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus","status":"UNKNOWN","sponsor":"Universidade Federal do Rio de Janeiro","startDate":"2006-10","conditions":"Dry Eye Syndromes, HIV Seropositivity","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"sodium carboximethycellulose","genericName":"sodium carboximethycellulose","companyName":"Universidade Federal do Rio de Janeiro","companyId":"universidade-federal-do-rio-de-janeiro","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium carboxymethylcellulose is a cellulose derivative that acts as a viscous, water-soluble polymer to provide lubrication, moisture retention, and protective coating of mucosal surfaces. Used for Dry eye syndrome (artificial tears), Oral mucositis protection, Gastrointestinal mucosal protection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}