{"id":"sodium-bicarbonate-powder-and-ondansetron","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Metabolic alkalosis (sodium bicarbonate)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium bicarbonate acts as an antacid by neutralizing hydrochloric acid in the stomach, raising gastric pH and reducing acid-related symptoms. Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract, preventing nausea and vomiting from various causes including chemotherapy, post-operative states, and gastric irritation.","oneSentence":"This combination uses sodium bicarbonate to neutralize gastric acid and ondansetron to block serotonin receptors and prevent nausea and vomiting.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:08:24.978Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nausea and vomiting associated with gastric acid reflux"},{"name":"Post-operative nausea and vomiting"},{"name":"Chemotherapy-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT06478667","phase":"PHASE3","title":"The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-12-20","conditions":"Acute Myocarditis","enrollment":50},{"nctId":"NCT05006638","phase":"PHASE4","title":"Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity","status":"UNKNOWN","sponsor":"Aya Sabry Mohamed Mohamed","startDate":"2022-12","conditions":"Pesticide Poisoning","enrollment":62},{"nctId":"NCT04509258","phase":"PHASE4","title":"Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-10","conditions":"the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sodium Bicarbonate Powder and ondansetron","genericName":"Sodium Bicarbonate Powder and ondansetron","companyName":"Aya Sabry Mohamed Mohamed","companyId":"aya-sabry-mohamed-mohamed","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses sodium bicarbonate to neutralize gastric acid and ondansetron to block serotonin receptors and prevent nausea and vomiting. Used for Nausea and vomiting associated with gastric acid reflux, Post-operative nausea and vomiting, Chemotherapy-induced nausea and vomiting.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}