{"id":"sodium-bicarbonate-catheter-lock-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or phlebitis at catheter site"},{"rate":null,"effect":"Catheter occlusion"},{"rate":null,"effect":"Electrolyte imbalance (if solution leaks systemically)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium bicarbonate solution is instilled into central venous catheters as a lock solution to maintain catheter patency and reduce catheter-related bloodstream infections (CRBSIs). The alkaline pH inhibits bacterial adhesion and biofilm development on the catheter surface, which are primary mechanisms of infection and thrombosis in indwelling catheters.","oneSentence":"Sodium bicarbonate creates an alkaline environment within a catheter lumen to prevent biofilm formation and bacterial colonization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:33.260Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of catheter-related bloodstream infections (CRBSIs) in central venous catheters"},{"name":"Maintenance of central venous catheter patency"}]},"trialDetails":[{"nctId":"NCT04772209","phase":"NA","title":"Comparison of Effectiveness and Complications of Catheter Lock Solutions in Non-tunneled Hemodialysis Catheters","status":"COMPLETED","sponsor":"Zonguldak Ataturk State Hospital","startDate":"2021-02-01","conditions":"Catheter Blockage, Catheter-Related Infections, Dialysis Catheter; Thrombosis","enrollment":441},{"nctId":"NCT04054128","phase":"PHASE4","title":"Bicarbonate vs Heparin Catheter Lock in Chronic Hemodialysis Patients","status":"UNKNOWN","sponsor":"Hospital General \"Dr. Miguel Silva\" de Morelia","startDate":"2019-09-11","conditions":"End Stage Renal Disease, Vascular Access Complication, Catheter Complications","enrollment":60},{"nctId":"NCT03627884","phase":"PHASE4","title":"Outcomes of the Use of Sodium Bicarbonate (8.4%) Solution as a Catheter Lock Solution to Prevent Hemodialysis Catheter Loss Due to Lumen Clot Formation","status":"COMPLETED","sponsor":"Coney Island Hospital, Brooklyn, NY","startDate":"2016-10-01","conditions":"End Stage Renal Disease, Acute Renal Failure, Hemodialysis Catheter Infection","enrollment":451}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sodium Bicarbonate Catheter Lock Solution","genericName":"Sodium Bicarbonate Catheter Lock Solution","companyName":"Coney Island Hospital, Brooklyn, NY","companyId":"coney-island-hospital-brooklyn-ny","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium Bicarbonate Catheter Lock Solution is used to prevent complications associated with hemodialysis catheters, such as infection and failure. It is studied as an alternative to heparin for locking hemodialysis catheters in chronic hemodialysis patients.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}