{"id":"sodium-bicarbonate-4-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Metabolic alkalosis"},{"rate":null,"effect":"Phlebitis at injection site"}]},"_chembl":{"chemblId":"CHEMBL1353","moleculeType":"Small molecule","molecularWeight":"84.01"},"_dailymed":{"setId":"78c25911-0042-664e-e053-2a91aa0a57a1","title":"INFANT 4.2% SODIUM BICARBONATE INJECTION, SOLUTION [HF ACQUISITION CO LLC, DBA HEALTHFIRST]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium bicarbonate is a weak base that reacts with hydrogen ions to form water and carbon dioxide, thereby increasing bicarbonate concentration and raising pH. It is used to correct metabolic acidosis, alkalinize urine, and manage acute conditions where acid-base balance is disrupted. The 4.2% formulation is typically administered intravenously for rapid systemic effect.","oneSentence":"Sodium bicarbonate acts as a buffer to neutralize excess acid and raise pH in body fluids.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:54:21.335Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metabolic acidosis"},{"name":"Urinary alkalinization"},{"name":"Hyperkalemia management"},{"name":"Tricyclic antidepressant overdose"}]},"trialDetails":[{"nctId":"NCT03921346","phase":"NA","title":"Reducing Prehospital Medication Errors & Time to Drug Delivery by EMS During Simulated Pediatric CPR","status":"COMPLETED","sponsor":"Pediatric Clinical Research Platform","startDate":"2019-09-03","conditions":"Cardiopulmonary Arrest, Resuscitation, Pediatrics","enrollment":150},{"nctId":"NCT04010630","phase":"NA","title":"Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2019-10-07","conditions":"Metabolic Acidosis, Acute Kidney Injury","enrollment":640},{"nctId":"NCT06491485","phase":"PHASE4","title":"Postoperative Analgesia in Laparoscopic Gynecological Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-10-01","conditions":"Postoperative Pain","enrollment":90},{"nctId":"NCT02476253","phase":"PHASE3","title":"Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2015-05-05","conditions":"Metabolic Acidosis","enrollment":400},{"nctId":"NCT01370278","phase":"NA","title":"Clearance Of Mucus In Stents (COMIS)","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2011-06-16","conditions":"Lung Neoplasms, Respiratory Failure, Pneumonia","enrollment":43},{"nctId":"NCT04255121","phase":"PHASE3","title":"Bicarbonate Epidural Injection in Emergency Caesarian","status":"COMPLETED","sponsor":"CHU de Reims","startDate":"2020-06-22","conditions":"Emergency Caesarean","enrollment":400},{"nctId":"NCT03628430","phase":"NA","title":"Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia","status":"COMPLETED","sponsor":"Faculty of Medicine, Sousse","startDate":"2017-01-01","conditions":"Pain, Anesthesia, Local","enrollment":120},{"nctId":"NCT01748097","phase":"PHASE2, PHASE3","title":"Intravenous Bicarbonate To Verify The Correct Position of IV Catheters in Oncological Patients Oncological Patients Receiving Chemotherapy","status":"UNKNOWN","sponsor":"Sheba Medical Center","startDate":"2012-12","conditions":"Detection of the Correct Position of Intravenous Line","enrollment":100},{"nctId":"NCT01458873","phase":"PHASE2, PHASE3","title":"Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Spontaneously Breathing Adult Volunteers","status":"UNKNOWN","sponsor":"Sheba Medical Center","startDate":"2011-10","conditions":"Infiltration, Extravasation","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"sodium bicarbonate 4.2%","genericName":"sodium bicarbonate 4.2%","companyName":"Sheba Medical Center","companyId":"sheba-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium bicarbonate acts as a buffer to neutralize excess acid and raise pH in body fluids. Used for Metabolic acidosis, Urinary alkalinization, Hyperkalemia management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}