{"id":"sodium-aescinate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Aescin, the active component of horse chestnut seed extract, strengthens the blood-brain barrier and reduces fluid extravasation from capillaries. It inhibits hyaluronidase and other enzymes that degrade the capillary wall matrix, while also suppressing inflammatory cytokine production. This makes it effective for reducing cerebral edema and improving microcirculation.","oneSentence":"Sodium aescinate reduces vascular permeability and edema by stabilizing capillary endothelial cells and inhibiting inflammatory mediator release.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:37:49.694Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cerebral edema (post-traumatic, post-operative, or ischemic stroke)"},{"name":"Venous insufficiency and related edema"}]},"trialDetails":[{"nctId":"NCT07339631","phase":"PHASE1","title":"Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults","status":"RECRUITING","sponsor":"Xijing Hospital","startDate":"2026-03-01","conditions":"Low Back Pain, Paraspinal Muscle, CLBP - Chronic Low Back Pain","enrollment":40},{"nctId":"NCT05263167","phase":"PHASE4","title":"Reducing Edema After intraCerebral Hemorrhage","status":"UNKNOWN","sponsor":"Beijing Tiantan Hospital","startDate":"2022-03-15","conditions":"Edema Brain","enrollment":300},{"nctId":"NCT04247659","phase":"PHASE4","title":"Study on the Relationship Between Asymmetric Vascular Sign of Cortex and Prognosis in Massive Cerebral Infarction","status":"UNKNOWN","sponsor":"The Second Hospital of Hebei Medical University","startDate":"2020-01-09","conditions":"Cerebral Infarction, Cerebral Edema","enrollment":150}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"DYSPNOEA"},{"count":2,"reaction":"RASH"},{"count":1,"reaction":"ABDOMINAL DISTENSION"},{"count":1,"reaction":"ATRIAL FIBRILLATION"},{"count":1,"reaction":"CEREBROVASCULAR INSUFFICIENCY"},{"count":1,"reaction":"CONDITION AGGRAVATED"},{"count":1,"reaction":"DERMATITIS ALLERGIC"},{"count":1,"reaction":"DIZZINESS"},{"count":1,"reaction":"DRY THROAT"},{"count":1,"reaction":"ERYTHEMA"}],"_approvalHistory":[],"publicationCount":61,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sodium Aescinate for Injection"],"phase":"marketed","status":"active","brandName":"Sodium Aescinate","genericName":"Sodium Aescinate","companyName":"Beijing Tiantan Hospital","companyId":"beijing-tiantan-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium aescinate reduces vascular permeability and edema by stabilizing capillary endothelial cells and inhibiting inflammatory mediator release. Used for Cerebral edema (post-traumatic, post-operative, or ischemic stroke), Venous insufficiency and related edema.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}