{"id":"sobuzoxane","rwe":[{"pmid":"41103880","year":"2025","title":"Etoposide (VP-16)-Containing Oral Palliative Chemotherapies (OPCs) Are Well Tolerated by Elderly Patients With Aggressive Non-Hodgkin Lymphoma: A 10-Year Single-Institute Experience.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"40134998","year":"2025","title":"Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Presenting With Significant Villous Atrophy in the Small Intestine.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"39513061","year":"2024","title":"Methotrexate, Hydrocortisone, Vincristine, Sobuzoxane, and Etoposide Is an Effective Option for Relapsed T-cell Prolymphocytic Leukemia with Loss of CD52 Expression after Retreatment with Alemtuzumab.","finding":"","journal":"JMA journal","studyType":"Clinical Study"},{"pmid":"33656972","year":"2021","title":"Clinical feasibility of oral low-dose etoposide and sobuzoxane for conventional chemotherapy-intolerant lymphoma patients.","finding":"","journal":"Expert review of anticancer therapy","studyType":"Clinical Study"},{"pmid":"33551437","year":"2021","title":"MTX-HOPE is a low-dose salvage chemotherapy for aged patients with relapsed or refractory non-Hodgkin lymphoma.","finding":"","journal":"Journal of clinical and experimental hematopathology : JCEH","studyType":"Clinical Study"}],"tags":[{"label":"sobuzoxane","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Topoisomerase II Inhibitors","category":"pharmacology"},{"label":"Topoisomerase Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"perazolin","offLabel":[],"synonyms":["sobuzoxane","MST-16","perazolin"],"timeline":[],"approvals":[],"brandName":"Perazolin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"sobuzoxane","explanation":"Imagine your body's cells are like a complex network of roads. Perazolin is like a traffic controller that helps regulate the flow of information and materials between cells. By doing so, it may help to restore balance and normal function in the body, but the exact way it does this is still a mystery.","oneSentence":"Perazolin works by interacting with specific biological pathways, although the exact details of its mechanism are unclear.","technicalDetail":"Perazolin's mechanism of action is thought to involve modulation of specific biological pathways, although the precise molecular targets and downstream effects are currently unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2455","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SOBUZOXANE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:40:05.804059","biosimilars":[],"competitors":[],"genericName":"sobuzoxane","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"R1308VH37P","CHEBI":"CHEBI:32136","INN_ID":"6551","UMLSCUI":"C0378253","ChEMBL_ID":"CHEMBL1256871","KEGG_DRUG":"D01404","PUBCHEM_CID":"5233","MESH_SUPPLEMENTAL_RECORD_UI":"C057773"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":37,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sep","pmid":"41103880","title":"Etoposide (VP-16)-Containing Oral Palliative Chemotherapies (OPCs) Are Well Tolerated by Elderly Patients With Aggressive Non-Hodgkin Lymphoma: A 10-Year Single-Institute Experience.","journal":"Cureus"},{"date":"2025 Feb","pmid":"40134998","title":"Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Presenting With Significant Villous Atrophy in the Small Intestine.","journal":"Cureus"},{"date":"2024 Oct 15","pmid":"39513061","title":"Methotrexate, Hydrocortisone, Vincristine, Sobuzoxane, and Etoposide Is an Effective Option for Relapsed T-cell Prolymphocytic Leukemia with Loss of CD52 Expression after Retreatment with Alemtuzumab.","journal":"JMA journal"},{"date":"2021 Jul","pmid":"33656972","title":"Clinical feasibility of oral low-dose etoposide and sobuzoxane for conventional chemotherapy-intolerant lymphoma patients.","journal":"Expert review of anticancer therapy"},{"date":"2021 Mar 18","pmid":"33551437","title":"MTX-HOPE is a low-dose salvage chemotherapy for aged patients with relapsed or refractory non-Hodgkin lymphoma.","journal":"Journal of clinical and experimental hematopathology : JCEH"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Perazolin is a small molecule with synonyms SOBUZOXANE and SOBUZOXANO. Its exact mechanism and clinical uses are not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}