{"id":"smc021-oral-calcitonin","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Injection site reaction"},{"rate":"5-10%","effect":"Hypocalcemia"}]},"_chembl":{"chemblId":"CHEMBL4594242","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Calcitonin is a hormone produced by the thyroid gland that helps regulate calcium levels in the blood. By administering calcitonin orally, SMC021 Oral Calcitonin aims to reduce blood calcium levels in patients with hypercalcemia or other conditions where calcium regulation is disrupted.","oneSentence":"SMC021 Oral Calcitonin works by mimicking the action of the naturally occurring hormone calcitonin to lower blood calcium levels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:34:59.184Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of hypercalcemia of malignancy"}]},"trialDetails":[{"nctId":"NCT00486434","phase":"PHASE3","title":"Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis","status":"COMPLETED","sponsor":"Nordic Bioscience A/S","startDate":"2007-05","conditions":"Osteoarthritis","enrollment":1176},{"nctId":"NCT00704847","phase":"PHASE3","title":"Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)","status":"TERMINATED","sponsor":"Nordic Bioscience A/S","startDate":"2008-06","conditions":"Osteoarthritis","enrollment":1030},{"nctId":"NCT00525798","phase":"PHASE3","title":"A Study to Evaluate Oral Salmon Calcitonin in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D","status":"COMPLETED","sponsor":"Nordic Bioscience A/S","startDate":"2007-03","conditions":"Osteoporosis","enrollment":4665},{"nctId":"NCT00421590","phase":"PHASE2","title":"Drug Interaction of SMC021 With Concomitant Antacid (Calcium Carbonate/Magnesium Hydroxide).","status":"COMPLETED","sponsor":"Novartis","startDate":"2006-10","conditions":"Health Postmenopausal Women","enrollment":38},{"nctId":"NCT00395395","phase":"PHASE1","title":"Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy Postmenopausal Women","status":"COMPLETED","sponsor":"Novartis","startDate":"2006-10","conditions":"Postmenopausal Osteoporosis","enrollment":56},{"nctId":"NCT00411125","phase":"PHASE1","title":"Pharmacokinetics and Pharmacodynamics Study of Oral Salmon Calcitonin in Healthy Postmenopausal Women","status":"COMPLETED","sponsor":"Novartis","startDate":"2006-08","conditions":"Postmenopausal Osteoporosis","enrollment":86}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SMC021 Oral Calcitonin","genericName":"SMC021 Oral Calcitonin","companyName":"Nordic Bioscience A/S","companyId":"nordic-bioscience-a-s","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SMC021 Oral Calcitonin works by mimicking the action of the naturally occurring hormone calcitonin to lower blood calcium levels. Used for Treatment of hypercalcemia of malignancy.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}