{"id":"small-kit-rhbmp-2-with-local-autograft","safety":{"commonSideEffects":[{"rate":null,"effect":"Swelling/edema at surgical site"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Heterotopic ossification"},{"rate":null,"effect":"Seroma formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BMP-2 is a growth factor that activates osteoblasts and promotes differentiation of mesenchymal stem cells into bone-forming cells. When delivered locally with autograft bone, it enhances and accelerates bone healing and fusion. This combination leverages both the osteoinductive properties of rhBMP-2 and the structural/cellular support of autologous bone.","oneSentence":"rhBMP-2 (recombinant human bone morphogenetic protein-2) stimulates bone formation and osteoinduction when combined with autologous bone graft material.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:24.847Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spinal fusion surgery"},{"name":"Bone defect repair and regeneration"}]},"trialDetails":[{"nctId":"NCT03527966","phase":"PHASE4","title":"rhBMP-2 Versus Vivigen in Lumbar Fusion Procedures","status":"TERMINATED","sponsor":"Virtua Health, Inc.","startDate":"2017-07-03","conditions":"Lumbar Spine Degeneration","enrollment":3}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Small kit rhBMP-2 with local autograft","genericName":"Small kit rhBMP-2 with local autograft","companyName":"Virtua Health, Inc.","companyId":"virtua-health-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"rhBMP-2 (recombinant human bone morphogenetic protein-2) stimulates bone formation and osteoinduction when combined with autologous bone graft material. Used for Spinal fusion surgery, Bone defect repair and regeneration.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}