{"id":"small-intestinal-release-peppermint-oil","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact mechanism of peppermint oil in the small intestine is not fully understood, but it is thought to work by blocking calcium channels and reducing the release of acetylcholine, a neurotransmitter that stimulates muscle contractions.","oneSentence":"Peppermint oil works by relaxing the muscles in the small intestine, reducing spasms and cramping.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:35:03.180Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Irritable bowel syndrome (IBS) symptoms, including abdominal pain and cramping"}]},"trialDetails":[{"nctId":"NCT05799053","phase":"PHASE3","title":"Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2022-05-12","conditions":"Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Child","enrollment":228},{"nctId":"NCT06914921","phase":"NA","title":"Enteric-Coated Peppermint Oil Versus Standard Antispasmodic in SLC6A4 (5-HTTLPR) Carriers With Irritable Bowel Syndrome.","status":"COMPLETED","sponsor":"S.LAB (SOLOWAYS)","startDate":"2024-02-04","conditions":"Irritable Bowel Syndrome (IBS)","enrollment":224},{"nctId":"NCT02291445","phase":"PHASE2","title":"Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®), a Pharmacokinetic Study","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2015-03","conditions":"Irritable Bowel Syndrome, Abdominal Pain, Colonic Diseases","enrollment":8},{"nctId":"NCT02716285","phase":"PHASE3","title":"Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2016-08-17","conditions":"Irritable Bowel Syndrome, Abdominal Pain, Colonic Diseases, Functional","enrollment":190}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tempocol","Peppermint oil","Menthae piperitae aetheroleum","Tempocol®","A03AX15"],"phase":"phase_3","status":"active","brandName":"Small intestinal release peppermint oil","genericName":"Small intestinal release peppermint oil","companyName":"Maastricht University Medical Center","companyId":"maastricht-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Peppermint oil works by relaxing the muscles in the small intestine, reducing spasms and cramping. Used for Irritable bowel syndrome (IBS) symptoms, including abdominal pain and cramping.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}