{"id":"slow-dose-preemptive-atropine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Mydriasis (pupil dilation)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atropine is an anticholinergic agent that competitively antagonizes acetylcholine at muscarinic receptors throughout the central and peripheral nervous systems. When administered preemptively at low doses, it prevents the excessive cholinergic stimulation that occurs during organophosphate or nerve agent exposure, thereby blocking muscarinic symptoms such as excessive salivation, bronchospasm, and bradycardia.","oneSentence":"Slow dose preemptive atropine blocks muscarinic acetylcholine receptors to prevent cholinergic toxicity and organophosphate poisoning effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:24.886Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preemptive treatment for organophosphate or nerve agent exposure"},{"name":"Prevention of cholinergic crisis in high-risk occupational settings"}]},"trialDetails":[{"nctId":"NCT05892913","phase":"PHASE4","title":"The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients","status":"COMPLETED","sponsor":"Abant Izzet Baysal University","startDate":"2023-07-19","conditions":"Pregnancy, Cesarean Section, Anesthesia, Spinal","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Atropine"],"phase":"marketed","status":"active","brandName":"Slow dose preemptive Atropine","genericName":"Slow dose preemptive Atropine","companyName":"Abant Izzet Baysal University","companyId":"abant-izzet-baysal-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Slow dose preemptive atropine blocks muscarinic acetylcholine receptors to prevent cholinergic toxicity and organophosphate poisoning effects. Used for Preemptive treatment for organophosphate or nerve agent exposure, Prevention of cholinergic crisis in high-risk occupational settings.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}