{"id":"six-percent-hydroxy-ethyl-starch-130-0-4","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Coagulopathy"},{"rate":null,"effect":"Increased transfusion requirements"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL2108701","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"HES 130/0.4 is a third-generation synthetic colloid composed of hydroxyethyl starch with a molecular weight of 130 kDa and degree of substitution of 0.4. It functions as a volume expander used in fluid resuscitation, maintaining intravascular volume and improving microcirculation by virtue of its colloid osmotic properties. The 6% concentration provides a balanced approach to plasma volume expansion with reduced risk of hyperchloremic acidosis compared to earlier HES formulations.","oneSentence":"Hydroxyethyl starch (HES) 130/0.4 is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and maintaining fluid in the vascular space.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:34:56.232Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fluid resuscitation in acute blood loss and hypovolemia"},{"name":"Perioperative volume management in cardiovascular surgery"}]},"trialDetails":[{"nctId":"NCT05223361","phase":"PHASE3","title":"Cardiopulmonary Bypass Prime Solution in Patients Undergoing Heart Valve Surgery","status":"COMPLETED","sponsor":"Rajaie Cardiovascular Medical and Research Center","startDate":"2016-04","conditions":"Heart Valve Diseases","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Six percent hydroxy ethyl starch 130/0.4","genericName":"Six percent hydroxy ethyl starch 130/0.4","companyName":"Rajaie Cardiovascular Medical and Research Center","companyId":"rajaie-cardiovascular-medical-and-research-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxyethyl starch (HES) 130/0.4 is a synthetic colloid that expands intravascular volume by increasing plasma oncotic pressure and maintaining fluid in the vascular space. Used for Fluid resuscitation in acute blood loss and hypovolemia, Perioperative volume management in cardiovascular surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}