{"id":"sipv-dtap-hepa","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, redness, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability or fussiness"},{"rate":null,"effect":"Drowsiness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"sIPV+DTaP+HepA is a pentavalent combination vaccine containing inactivated poliovirus vaccine (sIPV), diphtheria and tetanus toxoids with acellular pertussis vaccine (DTaP), and hepatitis A virus antigen. It stimulates humoral and cellular immune responses to prevent infection by these five pathogens. The vaccine works by presenting antigens that trigger B and T cell responses, leading to production of protective antibodies and memory immunity.","oneSentence":"This combination vaccine provides immunization against poliomyelitis, diphtheria, tetanus, pertussis, and hepatitis A through inactivated viral and bacterial antigens.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:15.688Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of poliomyelitis"},{"name":"Prevention of diphtheria"},{"name":"Prevention of tetanus"},{"name":"Prevention of pertussis"},{"name":"Prevention of hepatitis A"}]},"trialDetails":[{"nctId":"NCT04636827","phase":"PHASE4","title":"Evaluation of Safety and Immunogenicity of Combined Immunization of sIPV, DTaP and HepA","status":"UNKNOWN","sponsor":"China National Biotec Group Company Limited","startDate":"2020-11-11","conditions":"Vaccination","enrollment":600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"sIPV+DTaP+HepA","genericName":"sIPV+DTaP+HepA","companyName":"China National Biotec Group Company Limited","companyId":"china-national-biotec-group-company-limited","modality":"Biologic","firstApprovalDate":"","aiSummary":"This combination vaccine provides immunization against poliomyelitis, diphtheria, tetanus, pertussis, and hepatitis A through inactivated viral and bacterial antigens. Used for Prevention of poliomyelitis, Prevention of diphtheria, Prevention of tetanus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}