{"id":"sinecatechins-10-topical-ointment","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sinecatechins, derived from green tea, have been shown to have antiviral properties, specifically targeting the E6 and E7 proteins of HPV, which are responsible for the proliferation of infected cells. This mechanism of action is thought to contribute to the therapeutic effects of sinecatechins in treating external genital warts.","oneSentence":"Sinecatechins 10% topical ointment works by inhibiting the replication of human papillomavirus (HPV) in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:53:12.051Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of external genital warts"}]},"trialDetails":[{"nctId":"NCT07137819","phase":"PHASE3","title":"Phase 3 - Evaluation of Veregen® 10% Ointment as New Herbal Topical Treatment for Actinic Keratosis","status":"RECRUITING","sponsor":"Aresus Pharma GmbH","startDate":"2024-09-04","conditions":"Actinic Keratosis of Face and Scalp","enrollment":280},{"nctId":"NCT04055142","phase":"PHASE3","title":"Clinical Trial for Evaluating the Efficacy and Safety of Electrocoagulation vs Topic Sinecatechins vs Topic Cidofovir Within the Treatment to High-grade Anal Intraepithelial Neoplasia in HIV Homosexual Males","status":"COMPLETED","sponsor":"Hospital Universitari Vall d'Hebron Research Institute","startDate":"2020-09-18","conditions":"High-grade Anal Intraepithelial Neoplasia","enrollment":108},{"nctId":"NCT03682601","phase":"PHASE2","title":"Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatment","status":"TERMINATED","sponsor":"GTO Pharmaceutical, LLC","startDate":"2018-08-30","conditions":"Sexual Pain Disorders, Postmenopausal Symptoms, Vulvovaginal Atrophy","enrollment":32},{"nctId":"NCT02622568","phase":"PHASE4","title":"Investigating Veregen ™ 15% Ointment Treatment For Non-facial Verrucae in Pediatric Patients: A Pilot Study","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2015-07","conditions":"Verruca, Warts","enrollment":28},{"nctId":"NCT02029352","phase":"PHASE2, PHASE3","title":"Topical Green Tea Ointment in Treatment of Superficial Skin Cancer","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2014-11","conditions":"Carcinoma, Basal Cell","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Veregen ointment"],"phase":"phase_3","status":"active","brandName":"sinecatechins 10% topical ointment","genericName":"sinecatechins 10% topical ointment","companyName":"Hospital Universitari Vall d'Hebron Research Institute","companyId":"hospital-universitari-vall-d-hebron-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sinecatechins 10% topical ointment works by inhibiting the replication of human papillomavirus (HPV) in the skin. Used for Treatment of external genital warts.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}