{"id":"simplified-intensive-insulin-therapy-regimen","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL1201631","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a therapeutic regimen rather than a molecular drug, designed to optimize insulin delivery through a simplified protocol that reduces complexity while maintaining efficacy. The approach typically combines long-acting basal insulin with rapid-acting bolus insulin at meals, but with fewer injections or simplified dosing algorithms compared to standard intensive regimens. The goal is to improve patient adherence and glycemic outcomes while reducing the burden of complex insulin management.","oneSentence":"A simplified insulin dosing regimen that delivers basal and bolus insulin in a more streamlined manner to improve glycemic control in diabetes patients.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:08:02.216Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus requiring insulin therapy"}]},"trialDetails":[{"nctId":"NCT03972982","phase":"PHASE4","title":"Effects of Structured Simplified Short-term Intensive Insulin Therapy on Long-term Glycemic Remission","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2019-06-01","conditions":"Newly Diagnosed Type 2 Diabetes, Simplified Short-term Intensive Insulin Therapy, Glycemic Remission","enrollment":330}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Simplified intensive insulin therapy regimen","genericName":"Simplified intensive insulin therapy regimen","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A simplified insulin dosing regimen that delivers basal and bolus insulin in a more streamlined manner to improve glycemic control in diabetes patients. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus requiring insulin therapy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}