{"id":"simetride","rwe":[{"pmid":"3349478","year":"1988","title":"Reversal of resistance to vincristine in P388 leukemia by various polycyclic clinical drugs, with a special emphasis on quinacrine.","finding":"","journal":"Cancer research","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Pain","category":"indication"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=SIMETRIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:53:30.607652+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:53:36.395221+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SIMETRIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:53:37.211214+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2104924/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:53:38.032254+00:00"}},"allNames":["simetride"],"offLabel":[],"synonyms":["simetride"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"Kyorin Pharmaceutical Co., Ltd.","regulator":"PMDA"}],"ecosystem":[{"indication":"Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"bromfenac","slug":"bromfenac","company":"Bausch And Lomb Inc"},{"name":"butorphanol","slug":"butorphanol","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"}],"globalPrevalence":1500000000}],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"SIMETRIDE is a small molecule that binds to a specific receptor or enzyme, modulating its activity to produce analgesic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4883","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SIMETRIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:37:43.665595","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:53:39.769238+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"simetride","indications":{"approved":[{"name":"Pain","source":"DrugCentral","snomedId":22253000,"regulator":"FDA","usPrevalence":51600000,"globalPrevalence":1500000000,"prevalenceMethod":"curated","prevalenceSource":"CDC, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"QU6P2P8XLW","INN_ID":"2282","UMLSCUI":"C2348204","chemblId":"CHEMBL2104924","ChEMBL_ID":"CHEMBL2104924","KEGG_DRUG":"D01962","PUBCHEM_CID":"71622"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"Kyorin Pharmaceutical Co., Ltd.","relationship":"PMDA Licensee"}],"publicationCount":1,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"1988 Apr 15","pmid":"3349478","title":"Reversal of resistance to vincristine in P388 leukemia by various polycyclic clinical drugs, with a special emphasis on quinacrine.","journal":"Cancer research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"SIMETRIDE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"JP","regulator":"PMDA","status":"approved","approval_date":null,"mah":"Kyorin Pharmaceutical Co., Ltd.","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:53:39.769238+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}