{"id":"simethicone-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Minimal adverse events reported"}]},"_chembl":{"chemblId":"CHEMBL4297192","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Simethicone is a silicone-based antifoaming agent that works as a surfactant to break down foam and reduce the surface tension of gas bubbles in the stomach and intestines. By coalescencing smaller bubbles into larger ones, it facilitates their passage through the GI tract and reduces bloating, pressure, and discomfort. It is not absorbed systemically and acts locally within the gastrointestinal lumen.","oneSentence":"Simethicone reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:37.954Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bloating, gas, and abdominal discomfort"},{"name":"Flatulence"},{"name":"Functional dyspepsia"}]},"trialDetails":[{"nctId":"NCT07293234","phase":"NA","title":"Effect of Simethicone on Helicobacter Pylori Detection in Routine Endoscopy","status":"NOT_YET_RECRUITING","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2026-01","conditions":"H Pylori Infection","enrollment":100},{"nctId":"NCT06696209","phase":"NA","title":"To Evaluate the Best Metric for Inspection Time During a Diagnostic and/or Surveillance Upper Gastrointestinal Endoscopy (Age ≥ 18 Years, Informed Consent), Between Total Inspection Time Versus Withdrawal Time, for the Identification of Malignant Lesions","status":"RECRUITING","sponsor":"Portuguese Oncology Institute, Coimbra","startDate":"2025-03-07","conditions":"Premalignant Conditions, Malignant Lesions, Gastric","enrollment":1290},{"nctId":"NCT06919120","phase":"PHASE4","title":"The Study on the Effect of Different Administration Methods of Simethicone in Reducing Bubbles During Bowel Preparation","status":"NOT_YET_RECRUITING","sponsor":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","startDate":"2025-06-01","conditions":"Colonoscopy","enrollment":3},{"nctId":"NCT04487834","phase":"PHASE2","title":"Effects of Vivatlac Baby on Crying Behavior of Colicky Babies","status":"COMPLETED","sponsor":"The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz","startDate":"2020-04-16","conditions":"Infantile Colic","enrollment":87},{"nctId":"NCT04479423","phase":"NA","title":"The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy","status":"COMPLETED","sponsor":"Changhai Hospital","startDate":"2020-12-03","conditions":"Gastric Disease, Capsule Endoscopy","enrollment":252},{"nctId":"NCT05559814","phase":"NA","title":"Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2021-03-01","conditions":"Colonic Polyp","enrollment":404},{"nctId":"NCT02588248","phase":"PHASE3","title":"L-Menthol Injection as a Novel Technique During Colonoscopy","status":"TERMINATED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2017-04-27","conditions":"Colonic Polyps, Colon Cancer","enrollment":82},{"nctId":"NCT04802785","phase":"PHASE2, PHASE3","title":"The Impact of Air Travel on Passenger Cognitive Functions","status":"UNKNOWN","sponsor":"Dinara Zhumanbayeva","startDate":"2021-06","conditions":"Air Travel","enrollment":50},{"nctId":"NCT04666324","phase":"NA","title":"Effects of Multilac Baby on Fecal Calprotectin Levels of Colicky Babies","status":"UNKNOWN","sponsor":"The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz","startDate":"2020-12","conditions":"Infantile Colic","enrollment":100},{"nctId":"NCT04641455","phase":"NA","title":"Use of Mucolytic Solution Before Upper Endoscopy","status":"UNKNOWN","sponsor":"Vitkovice Hospital","startDate":"2020-12-01","conditions":"Gastric Cancer, Gastroscopy","enrollment":120},{"nctId":"NCT03742232","phase":"PHASE4","title":"Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen.","status":"COMPLETED","sponsor":"Istituto Clinico Humanitas","startDate":"2018-10-31","conditions":"Colon Polyp, Colon Adenoma, Colon Lesion","enrollment":399},{"nctId":"NCT02523911","phase":"NA","title":"Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening","status":"WITHDRAWN","sponsor":"MercyOne Des Moines Medical Center","startDate":"2016-03","conditions":"Colorectal Cancer","enrollment":""},{"nctId":"NCT03776916","phase":"NA","title":"Application of Simethicone in Esophagogastroscopy","status":"COMPLETED","sponsor":"Affiliated Hospital to Academy of Military Medical Sciences","startDate":"2019-05-01","conditions":"Gastric Disease","enrollment":311},{"nctId":"NCT03119168","phase":"PHASE4","title":"Effect of Simethicone on Screening Colonoscopy","status":"COMPLETED","sponsor":"Texas Tech University Health Sciences Center, El Paso","startDate":"2017-03-15","conditions":"Adenoma Colon","enrollment":268},{"nctId":"NCT03410524","phase":"PHASE3","title":"Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy","status":"COMPLETED","sponsor":"University of Nevada, Reno","startDate":"2018-01-09","conditions":"Colonoscopy","enrollment":250},{"nctId":"NCT02486536","phase":"PHASE4","title":"The Best Dosage and Timing of Polyethylene Glycol for Bowel Preparation Before Capsule Endoscopy","status":"COMPLETED","sponsor":"Zhizheng Ge","startDate":"2015-07","conditions":"Small Bowel Disease","enrollment":410},{"nctId":"NCT02708238","phase":"PHASE4","title":"Efficacy of Matricariae Chamomilla L., Melissa Officinalis L. and Tyndallized Lactobacillus Acidophilus (H122) for Infantile Colics","status":"COMPLETED","sponsor":"Federico II University","startDate":"2014-04","conditions":"Infantile Colics","enrollment":180},{"nctId":"NCT02555228","phase":"PHASE2, PHASE3","title":"Small Volume Simethicone Before Gastroscopy: Any Benefit?","status":"COMPLETED","sponsor":"Changi General Hospital","startDate":"2015-08","conditions":"Lesion of Stomach","enrollment":54},{"nctId":"NCT02548403","phase":"PHASE3","title":"Effect of Simethicone on Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Korea University Anam Hospital","startDate":"2014-07","conditions":"Colorectal Cancer","enrollment":260},{"nctId":"NCT01626976","phase":"PHASE1","title":"A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects","status":"COMPLETED","sponsor":"Pfizer","startDate":"2012-06","conditions":"Healthy","enrollment":42},{"nctId":"NCT01783782","phase":"PHASE4","title":"Small Bowel Cleansing for Capsule Endoscopy in Pediatric Patients","status":"UNKNOWN","sponsor":"Azienda Policlinico Umberto I","startDate":"2005-11","conditions":"Capsule Endoscopy","enrollment":200},{"nctId":"NCT01711437","phase":"PHASE4","title":"Different Bowel Preparations for Colonoscopy In Children","status":"UNKNOWN","sponsor":"Azienda Policlinico Umberto I","startDate":"2011-01","conditions":"Colonoscopy","enrollment":400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Simethicone","Control Group","Simethicone manufactured by Taejoon Pharm Co., Ltd.","mylicon"],"phase":"marketed","status":"active","brandName":"Simethicone Solution","genericName":"Simethicone Solution","companyName":"University of Nevada, Reno","companyId":"university-of-nevada-reno","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Simethicone reduces surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily. Used for Bloating, gas, and abdominal discomfort, Flatulence, Functional dyspepsia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":3,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}