{"id":"silymarine-supplementation","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Allergic reaction (rare)"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL5308485","moleculeType":null,"molecularWeight":"482.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Silymarin contains active compounds (primarily silibinin) that function as antioxidants and anti-inflammatory agents, protecting hepatocytes from toxin-induced damage and enhancing detoxification pathways. It stabilizes cell membranes, inhibits lipid peroxidation, and may promote protein synthesis and liver cell regeneration. The mechanism is thought to involve free radical scavenging and modulation of inflammatory signaling pathways.","oneSentence":"Silymarin is a flavonolignan extract from milk thistle that acts as a hepatoprotective agent by reducing oxidative stress and supporting liver cell regeneration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:34:34.364Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver disease support and hepatoprotection"},{"name":"Drug-induced liver injury prevention or treatment"}]},"trialDetails":[{"nctId":"NCT06801886","phase":"PHASE3","title":"Silymarin's Advantage on Graft Effectiveness","status":"ENROLLING_BY_INVITATION","sponsor":"University Hospital, Martin","startDate":"2020-01-07","conditions":"Posttransplant Diabetes Mellitus, Acute Graft Rejection, Biopsy Proven Acute Rejection","enrollment":130}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":188,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Silymarine supplementation","genericName":"Silymarine supplementation","companyName":"University Hospital, Martin","companyId":"university-hospital-martin","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Silymarin is a flavonolignan extract from milk thistle that acts as a hepatoprotective agent by reducing oxidative stress and supporting liver cell regeneration. Used for Liver disease support and hepatoprotection, Drug-induced liver injury prevention or treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}