{"id":"silymarin-capsule-simulant","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions (rare)"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Silymarin, derived from milk thistle seeds, acts as a potent antioxidant that scavenges free radicals and inhibits lipid peroxidation in liver tissue. It stabilizes hepatocyte membranes, reduces inflammatory cytokine production, and enhances protein synthesis to support liver cell recovery and regeneration. The compound also modulates phase I and II detoxification enzymes, improving the liver's capacity to metabolize xenobiotics and toxins.","oneSentence":"Silymarin is a flavonolignan mixture that protects hepatocytes through antioxidant and anti-inflammatory mechanisms, stabilizing cell membranes and promoting liver regeneration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:08:02.861Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver protection and support in hepatic disorders"},{"name":"Adjunctive therapy for chronic liver disease"},{"name":"Drug-induced liver injury prevention"}]},"trialDetails":[{"nctId":"NCT05042245","phase":"PHASE4","title":"The Efficacy and Safety of Ornithine Aspartic Acid Granules in NAFLD Against Silymarin Capsules","status":"COMPLETED","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2019-07-23","conditions":"Non-alcoholic Fatty Liver Disease","enrollment":237}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Silymarin capsule simulant","genericName":"Silymarin capsule simulant","companyName":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","companyId":"xinhua-hospital-shanghai-jiao-tong-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Silymarin is a flavonolignan mixture that protects hepatocytes through antioxidant and anti-inflammatory mechanisms, stabilizing cell membranes and promoting liver regeneration. Used for Liver protection and support in hepatic disorders, Adjunctive therapy for chronic liver disease, Drug-induced liver injury prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}