{"id":"silver-sulfadiazine-ointment","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or rash"},{"rate":null,"effect":"Argyria (blue-gray skin discoloration with prolonged use)"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Leukopenia (rare, with systemic absorption)"}]},"_chembl":{"chemblId":"CHEMBL1382627","moleculeType":"Small molecule","molecularWeight":"357.14"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Silver sulfadiazine is a topical antimicrobial agent combining silver's broad-spectrum bactericidal properties with sulfadiazine's sulfonamide mechanism. Silver ions denature bacterial proteins and interfere with cellular respiration, while sulfadiazine competitively inhibits bacterial dihydropteroate synthase, blocking folate synthesis essential for bacterial growth. This dual mechanism provides synergistic antimicrobial activity against a wide range of gram-positive and gram-negative bacteria.","oneSentence":"Silver sulfadiazine releases silver ions that inhibit bacterial cell wall synthesis and disrupt microbial DNA, while sulfadiazine inhibits folate synthesis in bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:07:59.491Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Burn wound infection prevention and treatment"},{"name":"Infected wounds and ulcers"},{"name":"Prevention of infection in minor cuts and abrasions"}]},"trialDetails":[{"nctId":"NCT05073172","phase":"NA","title":"StrataXRT for the Prevention and Treatment of Radiation Dermatitis in Breast Cancer or Head and Neck Cancer Patients","status":"WITHDRAWN","sponsor":"OHSU Knight Cancer Institute","startDate":"2024-01-01","conditions":"Breast Carcinoma, Head and Neck Carcinoma, Radiation-Induced Dermatitis","enrollment":""},{"nctId":"NCT05535452","phase":"NA","title":"Photobiomodulation for Prevention of Radiodermatitis in Women With Breast Cancer Undergoing Adjuvant Radiotherapy","status":"UNKNOWN","sponsor":"Instituto Nacional de Cancer, Brazil","startDate":"2023-02-06","conditions":"Radiodermatitis","enrollment":148},{"nctId":"NCT00787592","phase":"","title":"SSD vs Collagenase in Pediatric Burn Patients","status":"COMPLETED","sponsor":"Children's Mercy Hospital Kansas City","startDate":"2008-01","conditions":"Burns","enrollment":100},{"nctId":"NCT03162367","phase":"PHASE2","title":"Efficacy Of Autologous Epidermal Cell Suspension And Silver Sulfadiazine Ointment In Burn","status":"COMPLETED","sponsor":"SCARM Institute, Tabriz, Iran","startDate":"2019-04-10","conditions":"Burn","enrollment":40},{"nctId":"NCT03592498","phase":"PHASE2","title":"Study to Evaluate the Use of Tilapia Skin (Oreochromis Niloticus), in the Treatment of Burn Wounds","status":"COMPLETED","sponsor":"Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara","startDate":"2016-10-05","conditions":"Burns","enrollment":63},{"nctId":"NCT02497326","phase":"NA","title":"Heparin for the Treatment of Burn Wound Pain","status":"UNKNOWN","sponsor":"King Edward Medical University","startDate":"2015-04","conditions":"Second Degree Burns","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Silvazine","Flamazine","Silvadene","Sliverex","SSD"],"phase":"marketed","status":"active","brandName":"Silver sulfadiazine ointment","genericName":"Silver sulfadiazine ointment","companyName":"SCARM Institute, Tabriz, Iran","companyId":"scarm-institute-tabriz-iran","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Silver sulfadiazine releases silver ions that inhibit bacterial cell wall synthesis and disrupt microbial DNA, while sulfadiazine inhibits folate synthesis in bacteria. Used for Burn wound infection prevention and treatment, Infected wounds and ulcers, Prevention of infection in minor cuts and abrasions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}