{"id":"silver-nanoparticles-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or staining"},{"rate":null,"effect":"Allergic sensitization"},{"rate":null,"effect":"Taste alteration"}]},"_chembl":{"chemblId":"CHEMBL1230866","moleculeType":"Small molecule","molecularWeight":"107.87"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Silver nanoparticles are known to have broad-spectrum antimicrobial properties through multiple mechanisms including direct contact with bacterial cell walls, generation of reactive oxygen species, and interference with bacterial metabolism. When formulated as a mouthwash, they target oral pathogens responsible for dental plaque, gingivitis, and other oral infections. The nanoparticle formulation allows for enhanced bioavailability and contact with oral tissues.","oneSentence":"Silver nanoparticles in mouthwash exert antimicrobial effects by disrupting bacterial cell membranes and inhibiting microbial growth in the oral cavity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:34:33.316Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antimicrobial therapy for dental plaque and gingivitis prevention"},{"name":"Oral cavity infection management"}]},"trialDetails":[{"nctId":"NCT07200063","phase":"NA","title":"Children Acceptance of AgNP Mouthwash Against Chlorhexidine Mouthwash","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-01","conditions":"Teeth Staining, Numbness of the Tongue and Soft Tissue, Bitter Taste","enrollment":60},{"nctId":"NCT06963788","phase":"PHASE3","title":"The Comparative Effects of Using 0.12% Chlorhexidine and Silver Nanoparticles Mouthwashes in Medical Students","status":"COMPLETED","sponsor":"Can Tho University of Medicine and Pharmacy","startDate":"2024-02-06","conditions":"Dental Plaque and Gingivitis","enrollment":95},{"nctId":"NCT04894409","phase":"NA","title":"Evaluation of Silver Nanoparticles for the Prevention of COVID-19","status":"COMPLETED","sponsor":"Cluster de Bioeconomia de Baja California, A.C","startDate":"2020-04-24","conditions":"Coronavirus Disease 2019 (COVID-19)","enrollment":231}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["AgNPs mouthwash"],"phase":"phase_3","status":"active","brandName":"Silver nanoparticles mouthwash","genericName":"Silver nanoparticles mouthwash","companyName":"Can Tho University of Medicine and Pharmacy","companyId":"can-tho-university-of-medicine-and-pharmacy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Silver nanoparticles in mouthwash exert antimicrobial effects by disrupting bacterial cell membranes and inhibiting microbial growth in the oral cavity. Used for Oral antimicrobial therapy for dental plaque and gingivitis prevention, Oral cavity infection management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}