{"id":"silicon-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Mild erythema at application site"}]},"_chembl":null,"_dailymed":{"setId":"7d5bf511-1bc3-47ee-9859-faf1782c6511","title":"VACCINE DETOX (ECHINACEA, UNSPECIFIED, GELSEMIUM SEMPERVIRENS ROOT, THUJA OCCIDENTALIS LEAFY TWIG, SOLIDAGO VIRGAUREA FLOWERING TOP, SILICON DIOXIDE, ALUMINUM) LIQUID [GROUPE CYRENNE INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Silicon gel products work by creating an occlusive layer that hydrates the stratum corneum and flattens scar tissue through sustained moisture and gentle compression. The gel is typically applied topically to hypertrophic or keloid scars, where it helps normalize collagen remodeling and reduce erythema over time.","oneSentence":"Silicon gel forms a protective barrier on the skin surface to reduce scar appearance and improve skin hydration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:34:41.972Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertrophic scars"},{"name":"Keloid scars"},{"name":"Post-surgical scars"}]},"trialDetails":[{"nctId":"NCT07399340","phase":"NA","title":"A Comparative Evaluation of the Role of Self-Adhesive Flowable Composite in Enhancing Sealant Retention Versus Conventional Pits and Fissure Sealant With and Without Fissurotomy in Permanent Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-03","conditions":"Pits and Fissure Sealants","enrollment":88},{"nctId":"NCT06992960","phase":"NA","title":"Evaluation of the Scar Healing Effects of ChitoCare Medical Scar Healing Gel in Women Undergoing Breast Reduction or Mastopexy Surgery (CHITOSCAR)","status":"NOT_YET_RECRUITING","sponsor":"Primex ehf","startDate":"2025-09","conditions":"Surgical Scars","enrollment":39},{"nctId":"NCT05466461","phase":"NA","title":"Clinical Assessment of Giomer Based Technology Versus Smart Bioactive Restoration in Carious Class V Cavities","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-06-01","conditions":"Dental Caries","enrollment":34},{"nctId":"NCT05400486","phase":"NA","title":"Comparison of the Additional Effects of Using TENS and Interferential Currents for the Treatment of Individuals With Chronic Nonspecific Neck Pain.","status":"COMPLETED","sponsor":"University of Nove de Julho","startDate":"2022-07-30","conditions":"Neck Pain, Chronic Pain","enrollment":75},{"nctId":"NCT06945393","phase":"","title":"ANTIPIGMENTING OR DEPIMENTING EFFICACY UNDER PART OF VISIBLE LIGHT","status":"COMPLETED","sponsor":"L'Oreal","startDate":"2021-10-21","conditions":"Visible Light Exposure on Healthy Back Skin","enrollment":30},{"nctId":"NCT06909812","phase":"PHASE3","title":"Silicone vs Pirfenidone in the Treatment of Hypertrophic Scars and Keloids","status":"COMPLETED","sponsor":"Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.","startDate":"2015-07-14","conditions":"Scars, Keloids, Hypertrophic Scar","enrollment":40},{"nctId":"NCT06796933","phase":"NA","title":"Effect of Bioptron on Scar Formation After Cesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-01-27","conditions":"Cesarean Section","enrollment":60},{"nctId":"NCT03394417","phase":"NA","title":"StrataXRT vs Standard Clinical Practice for the Prevention of Acute Dermatitis in Head and Neck Cancers Patients","status":"RECRUITING","sponsor":"National University Hospital, Singapore","startDate":"2018-11-08","conditions":"Head and Neck Cancers, Acute Radiation Dermatitis","enrollment":100},{"nctId":"NCT06480318","phase":"NA","title":"Effect of TENS of Intestınal Functıons, Pain and Analgesis Consumptıon Amount","status":"NOT_YET_RECRUITING","sponsor":"İlknur tura","startDate":"2024-09-01","conditions":"Colorectal Surgery, Pain, Postoperative","enrollment":70},{"nctId":"NCT05623423","phase":"NA","title":"Evaluation of Clinical Performance of Class IV Restoration Using Organically Modified Ceramic (OMNOCER) in Comparison to a Methacrylate Based Composite Resin","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-11-30","conditions":"Shade Match","enrollment":26},{"nctId":"NCT06358911","phase":"PHASE4","title":"A Clinical Study for the Effect of 4th Generation Poly AmidoAmine Dendrimer on Post-Bleaching Hypersensitivity and Shade Stability","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2021-11-13","conditions":"Tooth Hypersensitivity","enrollment":60},{"nctId":"NCT05853523","phase":"PHASE2","title":"The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison","status":"COMPLETED","sponsor":"University of L'Aquila","startDate":"2021-02-27","conditions":"Dentin Sensitivity","enrollment":44},{"nctId":"NCT04492839","phase":"NA","title":"Intestinal Adsorbent and Breath Gas Levels","status":"COMPLETED","sponsor":"Dr Anthony Hobson","startDate":"2019-08-13","conditions":"Gastroesophageal Reflux, Small Intestinal Bacterial Overgrowth","enrollment":20},{"nctId":"NCT04215432","phase":"NA","title":"Propolis Extract, Nanovitamin C and Nanovitamin E in Peri-implant Mucositis","status":"COMPLETED","sponsor":"Universidad Complutense de Madrid","startDate":"2018-05-01","conditions":"Peri-implant Mucositis","enrollment":46},{"nctId":"NCT02397785","phase":"NA","title":"Intra-vaginal Electrical Stimulation Device Compared to Sham Device for Chronic Pelvic Pain","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2015-04","conditions":"Pelvic Pain","enrollment":58},{"nctId":"NCT03641482","phase":"NA","title":"NBF Gingival Gel Application After Impacted Lower Third Molar Surgery","status":"COMPLETED","sponsor":"Universidad Complutense de Madrid","startDate":"2016-09-01","conditions":"Alveolar Osteitis","enrollment":13},{"nctId":"NCT00617825","phase":"NA","title":"Feasibility Study of Cryotherapy for Chronic Venous Disorders","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2007-09","conditions":"Venous Insufficiency","enrollment":60},{"nctId":"NCT02584010","phase":"NA","title":"Efficacy Study of Two Silicon-based Products to Treat Scars","status":"WITHDRAWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2016-01","conditions":"Scars","enrollment":""},{"nctId":"NCT03019224","phase":"PHASE4","title":"Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2016-01","conditions":"Tooth Whitening, Sensitivity","enrollment":4},{"nctId":"NCT00859261","phase":"NA","title":"Two Dimensional (2D) Silicon Transducer-Compression Plates for Breast Ultrasound","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2009-03","conditions":"Breast Tumor, Breast Cysts","enrollment":21},{"nctId":"NCT01479127","phase":"PHASE2","title":"Study of Safety, Tolerability, Pharmacokinetics, and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's Disease","status":"COMPLETED","sponsor":"AbbVie (prior sponsor, Abbott)","startDate":"2011-10","conditions":"Advanced Parkinson's Disease","enrollment":8},{"nctId":"NCT02181166","phase":"NA","title":"Diagnosis and Management of Myofascial Pain Syndrome in Women With Mastectomies","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2014-08","conditions":"Breast Cancer, Myofascial Trigger Point","enrollment":60},{"nctId":"NCT01689857","phase":"NA","title":"Clinical Trial to Evaluate the Safety and Efficacy of Scarclinic™ Thin in Surgical Scars","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2010-10","conditions":"Hypertrophic Surgical Scar","enrollment":40},{"nctId":"NCT01004536","phase":"PHASE4","title":"An Investigator-blind Multi-center Prospective Study for the Efficacy and Safety of Silicon Gel (Dermatix)","status":"UNKNOWN","sponsor":"Samsung Medical Center","startDate":"2010-10","conditions":"Hypertrophic Cicatrix","enrollment":47}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":73,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Kelodacyn"],"phase":"marketed","status":"active","brandName":"silicon gel","genericName":"silicon gel","companyName":"Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.","companyId":"fundaci-n-nacional-para-la-ense-anza-y-la-investigaci-n-de-la-dermatolog-a-a-c","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Silicon gel forms a protective barrier on the skin surface to reduce scar appearance and improve skin hydration. Used for Hypertrophic scars, Keloid scars, Post-surgical scars.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}