{"id":"sibutramine-orlistat-diethylpropion","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal disturbances (orlistat-related)"},{"rate":null,"effect":"Increased heart rate"},{"rate":null,"effect":"Hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sibutramine acts as a noradrenergic and serotonergic reuptake inhibitor, increasing satiety and thermogenesis. Orlistat works peripherally in the gastrointestinal tract by blocking pancreatic and gastric lipases, preventing dietary fat absorption. Diethylpropion is a sympathomimetic that stimulates the central nervous system to reduce appetite. Together, these agents target weight loss through complementary pathways: central appetite suppression, peripheral fat malabsorption, and metabolic stimulation.","oneSentence":"This is a combination of three distinct weight-loss medications that work through different mechanisms: sibutramine inhibits norepinephrine and serotonin reuptake, orlistat inhibits pancreatic lipase to reduce fat absorption, and diethylpropion is a sympathomimetic amine that suppresses appetite.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:07:59.903Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Obesity management and weight loss"}]},"trialDetails":[{"nctId":"NCT00115063","phase":"PHASE4","title":"LOSS- Louisiana Obese Subjects Study","status":"TERMINATED","sponsor":"Pennington Biomedical Research Center","startDate":"2005-07","conditions":"Obesity","enrollment":390}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"sibutramine, orlistat, diethylpropion","genericName":"sibutramine, orlistat, diethylpropion","companyName":"Pennington Biomedical Research Center","companyId":"pennington-biomedical-research-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of three distinct weight-loss medications that work through different mechanisms: sibutramine inhibits norepinephrine and serotonin reuptake, orlistat inhibits pancreatic lipase to reduce fat absorption, and diethylpropion is a sympathomimetic amine that suppresses appetite. Used for Obesity management and weight loss.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}