{"id":"sibutramine-hydochloride-monohydrate","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Hypertension"},{"rate":"5-10","effect":"Tachycardia"},{"rate":"15-20","effect":"Headache"},{"rate":"10-15","effect":"Dry mouth"},{"rate":"10-15","effect":"Insomnia"},{"rate":"5-10","effect":"Constipation"},{"rate":"5-10","effect":"Increased heart rate"}]},"_chembl":{"chemblId":"CHEMBL3989830","moleculeType":"Small molecule","molecularWeight":"334.33"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sibutramine works primarily by inhibiting the reuptake of norepinephrine and serotonin in the hypothalamus and other brain regions involved in appetite regulation. This increases the availability of these neurotransmitters at synaptic sites, leading to enhanced feelings of fullness and decreased hunger. The drug also has a minor effect on dopamine reuptake inhibition.","oneSentence":"Sibutramine is a norepinephrine-serotonin reuptake inhibitor that increases satiety and reduces appetite by blocking the reuptake of these neurotransmitters in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:07:55.002Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Obesity management (withdrawn from most markets due to cardiovascular safety concerns)"}]},"trialDetails":[{"nctId":"NCT00234988","phase":"PHASE4","title":"A Phase IV, Multi-Center, Open-Label Trial of Sibutramine in Combination With a Hypocaloric Diet in Obese and Overweight Thai Subjects.","status":"COMPLETED","sponsor":"Abbott","startDate":"2004-06","conditions":"Obesity","enrollment":93}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ABT-991","sibutramine","Meridia"],"phase":"marketed","status":"active","brandName":"sibutramine hydochloride monohydrate","genericName":"sibutramine hydochloride monohydrate","companyName":"Abbott","companyId":"abbott","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sibutramine is a norepinephrine-serotonin reuptake inhibitor that increases satiety and reduces appetite by blocking the reuptake of these neurotransmitters in the central nervous system. Used for Obesity management (withdrawn from most markets due to cardiovascular safety concerns).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}