{"id":"short-ragweed-pollen-allergen-extract","brandName":"Short ragweed pollen allergen extract","genericName":"Short ragweed pollen allergen extract","companyId":"merck","companyName":"Merck Sharp & Dohme LLC","phase":"phase_3","status":"active","modality":"Biologic","aliases":["RAGWITEK™","MK-3641"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Ragweed pollen allergen extract is a sublingual immunotherapy developed by Merck Sharp & Dohme LLC for treating ragweed-induced rhinoconjunctivitis. It has completed several clinical trials, demonstrating efficacy and safety in both adults and children. The drug is not yet FDA-approved but shows promise as a non-invasive treatment option for allergic rhinitis.","enrichmentLevel":3,"visitCount":1,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved by gradually increasing the amount of short ragweed pollen in the extract, allowing the body to build up a tolerance and reducing symptoms associated with an allergic reaction. The exact mechanism is not fully understood, but it is believed to involve changes in the immune system's response to the allergen.","oneSentence":"Short ragweed pollen allergen extract works by desensitizing patients to short ragweed pollen through subcutaneous injections.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Injection site reactions"},{"rate":"5-10%","effect":"Allergic reactions"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Nausea"}]},"trials":[],"indications":{"approved":[{"name":"Treatment of short ragweed-induced allergic rhinitis with or without conjunctivitis symptoms"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}