{"id":"shark-cartilage-extract-ae-941","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Fatigue"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL5890926","moleculeType":null,"molecularWeight":"515.61"},"_fixedAt":"2026-03-30T17:42:26.430953","_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact mechanism of action is unclear, but AE-941 may interfere with the formation of new blood vessels, which can be beneficial in treating certain types of cancer. This is based on the presence of anti-angiogenic compounds in shark cartilage.","oneSentence":"AE-941, a shark cartilage extract, is thought to inhibit angiogenesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:58.959Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic colorectal cancer"}]},"_fixedFields":["pubmed(3)"],"trialDetails":[{"nctId":"NCT00005995","phase":"PHASE3","title":"AE-941 in Treating Patients With Metastatic Kidney Cancer","status":"COMPLETED","sponsor":"AEterna Zentaris","startDate":"2000-10","conditions":"Kidney Cancer","enrollment":""},{"nctId":"NCT00022282","phase":"PHASE2","title":"AE-941 in Treating Patients With Relapsed or Refractory Multiple Myeloma","status":"COMPLETED","sponsor":"AEterna Zentaris","startDate":"2001-04","conditions":"Multiple Myeloma and Plasma Cell Neoplasm","enrollment":""},{"nctId":"NCT00005838","phase":"PHASE3","title":"Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2000-03","conditions":"Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer","enrollment":756}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"recentPublications":[{"date":"2002","pmid":"26389205","title":"Cartilage (Bovine and Shark) (PDQ®): Health Professional Version.","journal":""},{"date":"2002","pmid":"26389175","title":"Cartilage (Bovine and Shark) (PDQ®): Patient Version.","journal":""},{"date":"2007 Nov","pmid":"17868728","title":"Prognostic factors of metastatic renal cell carcinoma after failure of immunotherapy: new paradigm from a large phase III trial with shark cartilage extract AE 941.","journal":"The Journal of urology"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["AE-941","Neovastat","Neovastat/AE-941"],"phase":"phase_3","status":"active","brandName":"shark cartilage extract AE-941","genericName":"shark cartilage extract AE-941","companyName":"AEterna Zentaris","companyId":"aeterna-zentaris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AE-941, a shark cartilage extract, is thought to inhibit angiogenesis. Used for Metastatic colorectal cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}