{"id":"sham-mpentoclo","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Bleeding"},{"rate":"5-10%","effect":"Thrombocytopenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Pentosan polysulfate sodium is a heparin-like anticoagulant that inhibits the coagulation cascade by binding to antithrombin III, thereby inhibiting the activity of factor Xa and thrombin. This leads to a decrease in the formation of blood clots.","oneSentence":"Pentosan polysulfate sodium is an anticoagulant that works by inhibiting the coagulation cascade.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:34:13.229Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Deep vein thrombosis"},{"name":"Pulmonary embolism"}]},"trialDetails":[{"nctId":"NCT06055257","phase":"PHASE3","title":"Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2025-01-16","conditions":"Osteoradionecrosis, Osteoradionecrosis of Jaw, Osteoradionecrosis of the Mandible","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Placebo"],"phase":"phase_3","status":"active","brandName":"sham mPENTOCLO","genericName":"sham mPENTOCLO","companyName":"Sunnybrook Health Sciences Centre","companyId":"sunnybrook-health-sciences-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pentosan polysulfate sodium is an anticoagulant that works by inhibiting the coagulation cascade. Used for Deep vein thrombosis, Pulmonary embolism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}