{"id":"sh-d-593-b-miranova","safety":{"commonSideEffects":[{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Amenorrhea"},{"rate":null,"effect":"Vaginal bleeding changes"}]},"_chembl":{"chemblId":"CHEMBL5819101","moleculeType":null,"molecularWeight":"483.52"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"As a selective progesterone receptor modulator (SPRM), SH D 593 B binds to progesterone receptors with tissue-selective activity, allowing both agonist and antagonist effects depending on the tissue context. This mechanism enables it to modulate endometrial proliferation and uterine contractility while potentially preserving ovarian function, making it suitable for conditions like uterine fibroids and endometriosis.","oneSentence":"SH D 593 B is a selective progesterone receptor modulator that modulates progesterone signaling to treat gynecological and reproductive disorders.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:52:59.257Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uterine fibroids (leiomyomas)"},{"name":"Endometriosis"}]},"trialDetails":[{"nctId":"NCT00185367","phase":"PHASE3","title":"Comparative Cycle Control Europe","status":"COMPLETED","sponsor":"Bayer","startDate":"2005-03","conditions":"Contraception","enrollment":798}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SH D 593 B (Miranova)","genericName":"SH D 593 B (Miranova)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SH D 593 B is a selective progesterone receptor modulator that modulates progesterone signaling to treat gynecological and reproductive disorders. Used for Uterine fibroids (leiomyomas), Endometriosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}