{"id":"sevelamer-carbonate-gz419831","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Constipation"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL5314347","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This mechanism is thought to be primarily through the formation of insoluble complexes with phosphate, which are then excreted in the feces. Sevelamer carbonate has been shown to be effective in reducing serum phosphate levels in patients with chronic kidney disease.","oneSentence":"Sevelamer carbonate is a phosphate binder that works by binding to phosphate in the gastrointestinal tract and preventing its absorption into the bloodstream.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:34:03.359Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic kidney disease, including hyperphosphatemia"}]},"trialDetails":[{"nctId":"NCT03001011","phase":"PHASE3","title":"Evaluation of Renvela in Patients With Chronic Kidney Disease Not On Dialysis And Hyperphosphatemia In China","status":"COMPLETED","sponsor":"Sanofi","startDate":"2017-06-07","conditions":"Hyperphosphatemia","enrollment":202}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Renvela"],"phase":"phase_3","status":"active","brandName":"Sevelamer Carbonate (GZ419831)","genericName":"Sevelamer Carbonate (GZ419831)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sevelamer carbonate is a phosphate binder that works by binding to phosphate in the gastrointestinal tract and preventing its absorption into the bloodstream. Used for Chronic kidney disease, including hyperphosphatemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}