{"id":"sertraline-srt","safety":{"commonSideEffects":[{"rate":"20-26%","effect":"Nausea"},{"rate":"12-18%","effect":"Diarrhea"},{"rate":"13-24%","effect":"Headache"},{"rate":"8-11%","effect":"Tremor"},{"rate":"10-16%","effect":"Insomnia"},{"rate":"15-25%","effect":"Sexual dysfunction"},{"rate":"5-13%","effect":"Somnolence"},{"rate":"9-16%","effect":"Dry mouth"}]},"_chembl":{"chemblId":"CHEMBL809","moleculeType":"Small molecule","molecularWeight":"306.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sertraline is a selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter protein, preventing the reabsorption of serotonin from the synaptic cleft back into presynaptic neurons. This increases serotonin concentration in the synapse, enhancing neurotransmission and producing antidepressant and anxiolytic effects. The mechanism is thought to normalize mood and reduce anxiety symptoms over time with chronic administration.","oneSentence":"Sertraline selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:34:01.322Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Obsessive-compulsive disorder"},{"name":"Panic disorder"},{"name":"Post-traumatic stress disorder"},{"name":"Social anxiety disorder"},{"name":"Generalized anxiety disorder"}]},"trialDetails":[{"nctId":"NCT01027559","phase":"NA","title":"fMRI Study of Treatment Changes in Major Depression","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2009-02","conditions":"Major Depression, Treatment","enrollment":97},{"nctId":"NCT00052078","phase":"PHASE3","title":"Child and Adolescent Anxiety Disorders (CAMS)","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2003-01","conditions":"Anxiety Disorders, Social Phobia, Generalized Anxiety Disorder","enrollment":488},{"nctId":"NCT01977729","phase":"PHASE2","title":"Sequencing CBT for Child Anxiety: CBT Plus Sertraline Versus Switch to Sertraline","status":"TERMINATED","sponsor":"Yale University","startDate":"2013-10","conditions":"Anxiety Disorder of Adolescence","enrollment":1}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":59,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zoloft"],"phase":"phase_3","status":"active","brandName":"Sertraline (SRT)","genericName":"Sertraline (SRT)","companyName":"Johns Hopkins University","companyId":"johns-hopkins-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sertraline selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain. Used for Major depressive disorder, Obsessive-compulsive disorder, Panic disorder.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}