{"id":"senna-cassia-naturetti","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Diarrhea"},{"rate":"5-15%","effect":"Abdominal cramps"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL2108558","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Senna and Cassia work by activating the muscarinic receptors in the intestinal smooth muscle, leading to increased peristalsis and bowel movements. This action is thought to be mediated by the anthraquinone glycosides present in these plants, which are metabolized to anthranoid compounds that stimulate the muscarinic receptors.","oneSentence":"Senna and Cassia are anthraquinone laxatives that stimulate bowel movements by increasing water and electrolyte secretion into the intestinal lumen.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:53.249Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation"}]},"trialDetails":[{"nctId":"NCT00994851","phase":"PHASE3","title":"Evaluation of Cassia Fistula + Senna Alexandrina Miller in the Chronic Functional Constipation Treatment.","status":"COMPLETED","sponsor":"Sanofi","startDate":"2009-09","conditions":"Constipation","enrollment":96},{"nctId":"NCT00931853","phase":"PHASE3","title":"Efficacy and Tolerability of Cassia Fistula Plus Senna Alexandrina Miller (Sugar Free) in the Chronic Functional Constipation (CFC).","status":"COMPLETED","sponsor":"Sanofi","startDate":"2010-09","conditions":"Constipation","enrollment":117}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SENNA+CASSIA(Naturetti)","genericName":"SENNA+CASSIA(Naturetti)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SENNA+CASSIA(Naturetti) is a combination of senna and cassia used to treat chronic functional constipation. The efficacy and tolerability of SENNA+CASSIA(Naturetti) have been studied in a phase III clinical trial.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}