{"id":"seloken-zok-toprol-xl","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL2356097","moleculeType":"Small molecule","molecularWeight":"652.83"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved by blocking the action of epinephrine on beta-1 receptors in the heart, which reduces the heart rate and the force of contraction. This leads to a decrease in blood pressure and a reduction in the workload of the heart.","oneSentence":"Seloken ZOK/Toprol-XL is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and slowing the heart rate and reducing its workload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:56.490Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Atrial fibrillation for stroke prevention"}]},"trialDetails":[{"nctId":"NCT00999102","phase":"PHASE4","title":"Nebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of Life","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2009-10","conditions":"Hypertension","enrollment":37},{"nctId":"NCT00038077","phase":"PHASE3","title":"Reversal of Ventricular Remodeling With Toprol-XL","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2001-08","conditions":"Heart Failure, Congestive","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Toprol-XL"],"phase":"phase_3","status":"active","brandName":"Seloken ZOK/Toprol-XL","genericName":"Seloken ZOK/Toprol-XL","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Seloken ZOK/Toprol-XL is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and slowing the heart rate and reducing its workload. Used for Hypertension, Angina pectoris, Atrial fibrillation for stroke prevention.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}